| Hippocampal plasticity in response to exercise in schizophrenia. | |
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MedLine Citation:
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PMID: 20124113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Hippocampal volume is lower than expected in patients with schizophrenia; however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to hippocampal plasticity. OBJECTIVE: To determine whether hippocampal volume would increase with exercise in humans and whether this effect would be related to improved aerobic fitness. DESIGN: Randomized controlled study. SETTING: Patients attending a day hospital program or an outpatient clinic. PATIENTS OR OTHER PARTICIPANTS: Male patients with chronic schizophrenia and matched healthy subjects. INTERVENTIONS: Aerobic exercise training (cycling) and playing table football (control group) for a period of 3 months. MAIN OUTCOME MEASURES: Magnetic resonance imaging of the hippocampus. Secondary outcome measures were magnetic resonance spectroscopy, neuropsychological (Rey Auditory Verbal Learning Test, Corsi block-tapping test), and clinical (Positive and Negative Syndrome Scale) features. RESULTS: Following exercise training, relative hippocampal volume increased significantly in patients (12%) and healthy subjects (16%), with no change in the nonexercise group of patients (-1%). Changes in hippocampal volume in the exercise group were correlated with improvements in aerobic fitness measured by change in maximum oxygen consumption (r = 0.71; P = .003). In the schizophrenia exercise group (but not the controls), change in hippocampal volume was associated with a 35% increase in the N-acetylaspartate to creatine ratio in the hippocampus. Finally, improvement in test scores for short-term memory in the combined exercise and nonexercise schizophrenia group was correlated with change in hippocampal volume (r = 0.51; P < .05). CONCLUSION: These results indicate that in both healthy subjects and patients with schizophrenia hippocampal volume is plastic in response to aerobic exercise. |
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Authors:
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Frank-Gerald Pajonk; Thomas Wobrock; Oliver Gruber; Harald Scherk; Dorothea Berner; Inge Kaizl; Astrid Kierer; Stephanie M?ller; Martin Oest; Tim Meyer; Martin Backens; Thomas Schneider-Axmann; Allen E Thornton; William G Honer; Peter Falkai |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of general psychiatry Volume: 67 ISSN: 1538-3636 ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 133-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, The Saarland University Hospital, Homburg, Germany. pajonk@klinik-dr-fontheim.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives, metabolism Chronic Disease Cognition Disorders / diagnosis, epidemiology Exercise* Hippocampus / anatomy & histology*, metabolism, physiopathology* Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Neuronal Plasticity / physiology* Neuropsychological Tests Schizophrenia / epidemiology, metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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