Document Detail

Hippocampal plasticity in response to exercise in schizophrenia.
MedLine Citation:
PMID:  20124113     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Hippocampal volume is lower than expected in patients with schizophrenia; however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to hippocampal plasticity. OBJECTIVE: To determine whether hippocampal volume would increase with exercise in humans and whether this effect would be related to improved aerobic fitness. DESIGN: Randomized controlled study. SETTING: Patients attending a day hospital program or an outpatient clinic. PATIENTS OR OTHER PARTICIPANTS: Male patients with chronic schizophrenia and matched healthy subjects. INTERVENTIONS: Aerobic exercise training (cycling) and playing table football (control group) for a period of 3 months. MAIN OUTCOME MEASURES: Magnetic resonance imaging of the hippocampus. Secondary outcome measures were magnetic resonance spectroscopy, neuropsychological (Rey Auditory Verbal Learning Test, Corsi block-tapping test), and clinical (Positive and Negative Syndrome Scale) features. RESULTS: Following exercise training, relative hippocampal volume increased significantly in patients (12%) and healthy subjects (16%), with no change in the nonexercise group of patients (-1%). Changes in hippocampal volume in the exercise group were correlated with improvements in aerobic fitness measured by change in maximum oxygen consumption (r = 0.71; P = .003). In the schizophrenia exercise group (but not the controls), change in hippocampal volume was associated with a 35% increase in the N-acetylaspartate to creatine ratio in the hippocampus. Finally, improvement in test scores for short-term memory in the combined exercise and nonexercise schizophrenia group was correlated with change in hippocampal volume (r = 0.51; P < .05). CONCLUSION: These results indicate that in both healthy subjects and patients with schizophrenia hippocampal volume is plastic in response to aerobic exercise.
Frank-Gerald Pajonk; Thomas Wobrock; Oliver Gruber; Harald Scherk; Dorothea Berner; Inge Kaizl; Astrid Kierer; Stephanie M?ller; Martin Oest; Tim Meyer; Martin Backens; Thomas Schneider-Axmann; Allen E Thornton; William G Honer; Peter Falkai
Related Documents :
20124113 - Hippocampal plasticity in response to exercise in schizophrenia.
17665473 - Aerobic and anaerobic exercise capacity in adolescents with juvenile idiopathic arthritis.
18580293 - Mechanics of breathing during exercise in men and women: sex versus body size differences?
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  67     ISSN:  1538-3636     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-43     Citation Subset:  AIM; IM    
Department of Psychiatry, The Saarland University Hospital, Homburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Chronic Disease
Cognition Disorders / diagnosis,  epidemiology
Hippocampus / anatomy & histology*,  metabolism,  physiopathology*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neuronal Plasticity / physiology*
Neuropsychological Tests
Schizophrenia / epidemiology,  metabolism,  physiopathology*
Reg. No./Substance:
56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication...
Next Document:  Long-Chain {omega}-3 Fatty Acids for Indicated Prevention of Psychotic Disorders: A Randomized, Plac...