| Hippocampal place cells encode intended destination, and not a discriminative stimulus, in a conditional T-maze task. | |
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MedLine Citation:
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PMID: 21365712 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The firing of hippocampal place cells encodes instantaneous location but can also reflect where the animal is heading (prospective firing), or where it has just come from (retrospective firing). The current experiment sought to explicitly control the prospective firing of place cells with a visual discriminada in a T-maze. Rats were trained to associate a specific visual stimulus (e.g., a flashing light) with the occurrence of reward in a specific location (e.g., the left arm of the T). A different visual stimulus (e.g., a constant light) signaled the availability of reward in the opposite arm of the T. After this discrimination had been acquired, rats were implanted with electrodes in the CA1 layer of the hippocampus. Place cells were then identified and recorded as the animals performed the discrimination task, and the presentation of the visual stimulus was manipulated. A subset of CA1 place cells fired at different rates on the central stem of the T depending on the animal's intended destination, but this conditional or prospective firing was independent of the visual discriminative stimulus. The firing rate of some place cells was, however, modulated by changes in the timing of presentation of the visual stimulus. Thus, place cells fired prospectively, but this firing did not appear to be controlled, directly, by a salient visual stimulus that controlled behavior. © 2011 Wiley-Liss, Inc. |
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Authors:
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James A Ainge; Minija Tamosiunaite; Florentin Wörgötter; Paul A Dudchenko |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-1 |
Journal Detail:
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Title: Hippocampus Volume: - ISSN: 1098-1063 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108167 Medline TA: Hippocampus Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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School of Psychology, University of St Andrews, St. Andrews. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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