| Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats. | |
| | |
MedLine Citation:
|
PMID: 18423578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Exercise can increase neurogenesis and affect gene expression in the brains of adult rats. Little is known about how exercise intensity affects neurogenesis and associated gene expression in juvenile rats. Here, we show that exercise influenced neurogenesis and mRNA expression of brain derived neurotrophic factor (BDNF), N-methyl-d-aspartate receptor type 1 (NMDAR1), vascular endothelial growth factor (VEGF) and fetal liver kinase-1 (Flk-1) in the hippocampus of 5 weeks old rats in an intensity-dependent manner. One week of low- or moderate-intensity exercise in a treadmill running task enhanced neurogenesis in the dentate gyrus of hippocampus. The low-, but not the high-, intensity exercise paradigm resulted in significantly increased expression of BDNF, NMDAR1, and Flk-1 mRNA. Gene expression levels in the low-intensity exercise group were greater than the high-intensity group for these four molecules. |
| | |
Authors:
|
Shu-jie Lou; Jin-yan Liu; Hui Chang; Pei-jie Chen |
Related Documents
:
|
23159258 - Exercise training and habitual physical activity: a randomized controlled trial. 12665538 - Control and quantitation of voluntary weight-lifting performance of rats. 23386078 - Physical exercise during pregnancy and its influence in the type of birth. 23127218 - Women's perceived benefits of exercise during and after breast cancer treatment. 10410838 - Water and electrolyte requirements for exercise. 11998068 - Enhancing self-esteem among cardiac patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-07 |
Journal Detail:
|
Title: Brain research Volume: 1210 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-05-12 Completed Date: 2008-08-26 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 48-55 Citation Subset: IM |
Affiliation:
|
Center of Exercise Molecular Biology, Department of Exercise and Sport Science, Shanghai University of Sport, 200 Hengren Road, Shanghai, 200438, China. shujielou319@yahoo.com.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology Animals Brain-Derived Neurotrophic Factor / genetics Bromodeoxyuridine Cell Count Cell Differentiation / genetics Cell Proliferation* Exercise Test Gene Expression Regulation, Developmental / genetics* Hippocampus / cytology, growth & development*, metabolism Male Neuronal Plasticity / genetics* Neurons / cytology, metabolism Physical Conditioning, Animal / physiology* Physical Exertion* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate / genetics Stem Cells / cytology, metabolism Up-Regulation / genetics Vascular Endothelial Growth Factor A / genetics Vascular Endothelial Growth Factor Receptor-2 / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Brain-Derived Neurotrophic Factor; 0/NR1 NMDA receptor; 0/RNA, Messenger; 0/Receptors, N-Methyl-D-Aspartate; 0/Vascular Endothelial Growth Factor A; 59-14-3/Bromodeoxyuridine; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility.
Next Document: Quantification of delayed oxygenation in ipsilateral primary motor cortex compared with contralatera...