| Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: a magnetic resonance study. | |
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MedLine Citation:
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PMID: 20974193 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Exposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180 min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. |
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Authors:
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Jiao-Jie Hui; Zhi-Jun Zhang; Shan-Shan Liu; Guang-Jun Xi; Xiang-Rong Zhang; Gao-Jun Teng; Kevin C Chan; Ed X Wu; Bin-Bin Nie; Bao-Ci Shan; Ling-Jiang Li; Gavin P Reynolds |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-23 |
Journal Detail:
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Title: Behavioural brain research Volume: 217 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, Affiliated ZhongDa Hospital and the Institution Neuropsychiatry of Southeast University, Nanjing, Jiangsu, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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