| Hippocampal mossy fiber sprouting induced by forced and voluntary physical exercise. | |
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MedLine Citation:
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PMID: 20515703 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Alterations in the function and organization of synapses have been proposed to induce learning and memory. Previous studies have demonstrated that mossy fiber induced by overtraining in a spatial learning task can be related with spatial long-term memory formation. In this work we analyzed whether physical exercise could induce mossy fiber sprouting by using a zinc-detecting histologic technique (Timm). Rats were submitted to 3 and 5days of forced or voluntary exercise. Rat brains were processed for Timm's staining to analyze mossy fiber projection at 7, 12 and 30days after the last physical exercise session. A significant increase of mossy fiber terminals in the CA3 stratum oriens region was observed after 5days of forced or voluntary exercise. Interestingly, the pattern of Timm's staining in CA3 mossy fibers was significantly altered when analyzed 12days after exercise but not at 7days post-exercise. In contrast, animals trained for only 3days did not show increments of mossy fiber terminals in the stratum oriens. Altogether, these results demonstrate that sustained or programmed exercise can alter mossy fiber sprouting. Further Investigations are necessary to determine whether mossy fiber sprouting induced by exercise is also involved in learning and memory processes. |
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Authors:
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Michelle Toscano-Silva; Sérgio Gomes da Silva; Fulvio Alexandre Scorza; Jean Jacques Bonvent; Esper Abrão Cavalheiro; Ricardo Mario Arida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Physiology & behavior Volume: 101 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 302-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Departamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 862, Ed. Ciências Biomédicas, 5 degrees andar. Vila Clementino, 04023-900, São Paulo (SP), Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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