Document Detail

Hippocampal morphology and distinguishing late-onset from early-onset elderly depression.
MedLine Citation:
PMID:  17986679     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Despite evidence for hippocampal abnormalities in elderly depression, it is unknown whether these changes are regionally specific. This study used three-dimensional mapping techniques to identify regional hippocampal abnormalities in early- and late-onset depression. Neuropsychological correlates of hippocampal morphology were also investigated.
METHOD: With high-resolution magnetic resonance imaging, hippocampal morphology was compared among elderly patients with early- (N=24) and late-onset (N=22) depression and comparison subjects (N=34). Regional structural abnormalities were identified by comparing distances, measured from homologous hippocampal surface points to the central core of each individual's hippocampal surface model, between groups.
RESULTS: Hippocampal volumes differed between depressed patients and comparison subjects but not between patients with early- and late-onset depression. However, statistical mapping results showed that regional surface contractions were significantly pronounced in late- compared to early-onset depression in the anterior of the subiculum and lateral posterior of the CA1 subfield in the left hemisphere. Significant shape differences were observed bilaterally in anterior CA1-CA3 subfields and the subiculum in patients in relation to comparison subjects. These results were similar when each disease group was separately compared to comparison subjects. Hippocampal surface contractions significantly correlated with memory measures among late- but not early-onset depressed patients or comparison subjects.
CONCLUSIONS: More pronounced regional volume deficits and their associations with memory in late-onset depression may suggest that these patients are more likely to develop cognitive impairment over time than individuals with early-onset depression. Mapping regional hippocampal abnormalities and their cognitive correlates may help guide research in defining risk profiles and treatment strategies.
Martina Ballmaier; Katherine L Narr; Arthur W Toga; Virginia Elderkin-Thompson; Paul M Thompson; Liberty Hamilton; Ebrahim Haroon; Daniel Pham; Andreas Heinz; Anand Kumar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-11-06
Journal Detail:
Title:  The American journal of psychiatry     Volume:  165     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-03-24     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  AIM; IM    
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MeSH Terms
Age of Onset
Atrophy / pathology
Brain Mapping
Cognition Disorders / diagnosis,  pathology,  psychology
Depressive Disorder, Major / diagnosis,  pathology*,  psychology
Diagnosis, Differential
Functional Laterality
Hippocampus / pathology*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / statistics & numerical data
Memory Disorders / diagnosis,  pathology,  psychology
Neuropsychological Tests / statistics & numerical data
Psychiatric Status Rating Scales / statistics & numerical data
Severity of Illness Index
Grant Support
K01 MH073990/MH/NIMH NIH HHS; K01 MH073990/MH/NIMH NIH HHS; K01 MH073990-04/MH/NIMH NIH HHS; K02 MH002043/MH/NIMH NIH HHS; K02 MH002043-05/MH/NIMH NIH HHS; K23 MH091254/MH/NIMH NIH HHS; MH-02043/MH/NIMH NIH HHS; MH-55115/MH/NIMH NIH HHS; MH-61567/MH/NIMH NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642-11/RR/NCRR NIH HHS; R01 MH055115/MH/NIMH NIH HHS; R01 MH055115-06/MH/NIMH NIH HHS; R01 MH061567/MH/NIMH NIH HHS; R01 MH061567-05/MH/NIMH NIH HHS; R01 MH063764/MH/NIMH NIH HHS; R01 MH063764-04/MH/NIMH NIH HHS; R01-MH-63674/MH/NIMH NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813-057523/RR/NCRR NIH HHS

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