| Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. | |
| | |
MedLine Citation:
|
PMID: 17986679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Despite evidence for hippocampal abnormalities in elderly depression, it is unknown whether these changes are regionally specific. This study used three-dimensional mapping techniques to identify regional hippocampal abnormalities in early- and late-onset depression. Neuropsychological correlates of hippocampal morphology were also investigated. METHOD: With high-resolution magnetic resonance imaging, hippocampal morphology was compared among elderly patients with early- (N=24) and late-onset (N=22) depression and comparison subjects (N=34). Regional structural abnormalities were identified by comparing distances, measured from homologous hippocampal surface points to the central core of each individual's hippocampal surface model, between groups. RESULTS: Hippocampal volumes differed between depressed patients and comparison subjects but not between patients with early- and late-onset depression. However, statistical mapping results showed that regional surface contractions were significantly pronounced in late- compared to early-onset depression in the anterior of the subiculum and lateral posterior of the CA1 subfield in the left hemisphere. Significant shape differences were observed bilaterally in anterior CA1-CA3 subfields and the subiculum in patients in relation to comparison subjects. These results were similar when each disease group was separately compared to comparison subjects. Hippocampal surface contractions significantly correlated with memory measures among late- but not early-onset depressed patients or comparison subjects. CONCLUSIONS: More pronounced regional volume deficits and their associations with memory in late-onset depression may suggest that these patients are more likely to develop cognitive impairment over time than individuals with early-onset depression. Mapping regional hippocampal abnormalities and their cognitive correlates may help guide research in defining risk profiles and treatment strategies. |
| | |
Authors:
|
Martina Ballmaier; Katherine L Narr; Arthur W Toga; Virginia Elderkin-Thompson; Paul M Thompson; Liberty Hamilton; Ebrahim Haroon; Daniel Pham; Andreas Heinz; Anand Kumar |
Related Documents
:
|
2399999 - Left prefrontal glucose hypometabolism in the depressed state: a confirmation. 15820239 - Activation in dorsolateral prefrontal cortex in response to maternal criticism and prai... 21813589 - The patient reported outcomes in lupus (patrol) study: role of depression in health-rel... 11525329 - Frontal cerebral perfusion dysfunction in elderly late-onset major depression assessed ... 16889109 - Nonpharmacological, somatic treatments of depression: electroconvulsive therapy and nov... 11343589 - Comparison of unlimited numbers of rapid transcranial magnetic stimulation (rtms) and e... 21255159 - Specific immunotherapy in asthma: efficacy and safety. 6418109 - Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. c... 8416059 - The association between lithium carbonate and smooth pursuit eye tracking among first-e... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-11-06 |
Journal Detail:
|
Title: The American journal of psychiatry Volume: 165 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-02-04 Completed Date: 2008-03-24 Revised Date: 2012-12-10 |
Medline Journal Info:
|
Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: United States |
Other Details:
|
Languages: eng Pagination: 229-37 Citation Subset: AIM; IM |
Affiliation:
|
Department of Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Berlin. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age of Onset Aged Atrophy / pathology Brain Mapping Cognition Disorders / diagnosis, pathology, psychology Depressive Disorder, Major / diagnosis, pathology*, psychology Diagnosis, Differential Female Functional Laterality Hippocampus / pathology* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / statistics & numerical data Male Memory Disorders / diagnosis, pathology, psychology Neuropsychological Tests / statistics & numerical data Psychiatric Status Rating Scales / statistics & numerical data Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
|
K01 MH073990/MH/NIMH NIH HHS; K01 MH073990/MH/NIMH NIH HHS; K01 MH073990-04/MH/NIMH NIH HHS; K02 MH002043-05/MH/NIMH NIH HHS; K23 MH091254-03/MH/NIMH NIH HHS; MH-02043/MH/NIMH NIH HHS; MH-55115/MH/NIMH NIH HHS; MH-61567/MH/NIMH NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642-11/RR/NCRR NIH HHS; R01 MH055115-06/MH/NIMH NIH HHS; R01 MH061567-05/MH/NIMH NIH HHS; R01 MH063764-04/MH/NIMH NIH HHS; R01-MH-63674/MH/NIMH NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813-057523/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Galantamine for the treatment of cognitive impairments in people with schizophrenia.
Next Document: Frequency of provider contact after FDA advisory on risk of pediatric suicidality with SSRIs.