Document Detail


Hippocampal morphology is differentially affected by reproductive experience in the mother.
MedLine Citation:
PMID:  16216005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy and mothering result in a number of hormonal, neurological, and behavioral changes that are necessary to ensure reproductive success. With subsequent reproductive experience (multiparity and mothering), further neurological and behavioral changes may result. Recent research has shown that previous motherhood enhances both hippocampus-dependent learning and memory and long-term potentiation (LTP); together with decreases in hippocampus volumes during pregnancy it is suggested that the hippocampus is affected by pregnancy and/or mothering. The present experiment aimed to investigate the effect of reproductive experience (nulli, primi-, and multiparity and mothering) on dendritic morphology in the CA1 and CA3 regions of the hippocampus. Brains were stained with a modified version of the single-section Golgi impregnation technique, and dendritic length, number of branch points, and spine density was analyzed for apical and basal regions of CA1 and CA3 pyramidal neurons. Primiparity and/or mothering resulted in dendritic remodeling in both the CA1 and CA3 hippocampal regions, and multiparity resulted in enhanced spine density in the basal CA1 region, which was positively correlated with number of male pups in a litter. These findings point to the effect of reproductive experience and offspring on plasticity in the hippocampus, an area not traditionally associated with motherhood.
Authors:
Jodi L Pawluski; Liisa A M Galea
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurobiology     Volume:  66     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2006-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-81     Citation Subset:  IM    
Affiliation:
Program in Neuroscience, Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Animals, Newborn
Cell Size*
Corticosterone / blood
Dendrites / ultrastructure
Dendritic Spines / ultrastructure
Estradiol / blood
Female
Hippocampus / cytology*
Neurons / cytology*
Parity / physiology*
Pregnancy
Random Allocation
Rats
Rats, Sprague-Dawley
Silver Staining / methods
Chemical
Reg. No./Substance:
50-22-6/Corticosterone; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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