| Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. | |
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MedLine Citation:
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PMID: 20176121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin regulates glucose uptake and storage in peripheral tissues, and has been shown to act within the hypothalamus to acutely regulate food intake and metabolism. The machinery for transduction of insulin signaling is also present in other brain areas, particularly in the hippocampus, but a physiological role for brain insulin outside the hypothalamus has not been established. Recent studies suggest that insulin may be able to modulate cognitive functions including memory. Here we report that local delivery of insulin to the rat hippocampus enhances spatial memory, in a PI-3-kinase dependent manner, and that intrahippocampal insulin also increases local glycolytic metabolism. Selective blockade of endogenous intrahippocampal insulin signaling impairs memory performance. Further, a rodent model of type 2 diabetes mellitus produced by a high-fat diet impairs basal cognitive function and attenuates both cognitive and metabolic responses to hippocampal insulin administration. Our data demonstrate that insulin is required for optimal hippocampal memory processing. Insulin resistance within the telencephalon may underlie the cognitive deficits commonly reported to accompany type 2 diabetes. |
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Authors:
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Ewan C McNay; Cecilia T Ong; Rory J McCrimmon; James Cresswell; Jonathan S Bogan; Robert S Sherwin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-20 |
Journal Detail:
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Title: Neurobiology of learning and memory Volume: 93 ISSN: 1095-9564 ISO Abbreviation: Neurobiol Learn Mem Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-07-30 Revised Date: 2011-09-19 |
Medline Journal Info:
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Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: United States |
Other Details:
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Languages: eng Pagination: 546-53 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Dept. of Psychology, University at Albany, Albany, NY 12222, USA. emcnay@albany.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Experimental / metabolism Diet Dietary Fats / metabolism Disease Models, Animal Hippocampus / drug effects, enzymology, physiology* Insulin / metabolism* Insulin Resistance / physiology* Male Memory / drug effects, physiology* Memory Disorders / metabolism Phosphatidylinositol 3-Kinases / metabolism Random Allocation Rats Rats, Sprague-Dawley Space Perception / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK 45735/DK/NIDDK NIH HHS; DK075772/DK/NIDDK NIH HHS; DK077106/DK/NIDDK NIH HHS; R01 DK075772-02/DK/NIDDK NIH HHS; R01 DK075772-03/DK/NIDDK NIH HHS; R01 DK075772-05/DK/NIDDK NIH HHS; R01 DK077106-01A1/DK/NIDDK NIH HHS; R01 DK077106-02/DK/NIDDK NIH HHS; R01 DK077106-03/DK/NIDDK NIH HHS; R01 DK077106-04/DK/NIDDK NIH HHS; R01 DK077106-05/DK/NIDDK NIH HHS; R37 DK020495-35/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 11061-68-0/Insulin; EC 2.7.1.-/Phosphatidylinositol 3-Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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