Document Detail

Hippocampal development at gestation weeks 23 to 36. An ultrasound study on preterm neonates.
MedLine Citation:
PMID:  20352419     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: During fetal development, the hippocampal structures fold around the hippocampal sulcus into the temporal lobe. According to the literature, this inversion should be completed at gestation week (GW) 21. Thereafter, the hippocampal shape should resemble the adult shape. However, incomplete hippocampal inversion (IHI) is found in 19% of the common population. The aim of this study was to study fetal hippocampal development by examining neonates born preterm. METHODS: We analyzed cranial ultrasound examinations, performed as a part of the routine assessment of all preterm infants, over a 3-year period and excluded the infants with brain pathology. The final material consisted of 158 children born <35 GW. A rounded form (the ratio between the horizontal and vertical diameters of the hippocampal body <or=1) in coronal slices was considered the sign of IHI. RESULTS: The age at examination was 23-24 GW in 24 neonates, 25-28 GW in 70 neonates, and 29-36 GW in 64 neonates. IHI was found in 50%, 24%, and 14%, respectively. The difference between the neonates <25 GW and >or=25 GW was statistically highly significant (p < 0.001). The frequency of bilateral IHI was highest in the youngest age group. In the other groups, the left-sided IHI was the most common. CONCLUSION: In about 50% of the neonates, hippocampal inversion is not completed up to GW 24; but from 25 GW onwards, the frequency and laterality of IHI is similar to that in the adult population.
Dragan Bajic; Uwe Ewald; Raili Raininko
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Publication Detail:
Type:  Journal Article     Date:  2010-03-30
Journal Detail:
Title:  Neuroradiology     Volume:  52     ISSN:  1432-1920     ISO Abbreviation:  Neuroradiology     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  489-94     Citation Subset:  IM    
Department of Radiology, University Hospital, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Hippocampus / abnormalities*,  growth & development,  ultrasonography*
Pregnancy Trimester, Third*
Premature Birth / ultrasonography*
Reproducibility of Results
Sensitivity and Specificity

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