| Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease. | |
| | |
MedLine Citation:
|
PMID: 20965261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent studies have demonstrated alterations in cortical gray to white matter tissue contrast with nondemented aging and in individuals with Alzheimer's disease (AD). However, little information exists about the clinical relevance of such changes. It is possible that changes in MRI tissue contrast occur via independent mechanisms from those traditionally used in the assessment of AD associated degeneration such as hippocampal degeneration measured by more traditional volumetric magnetic resonance imaging (MRI). We created cortical surface models of 95 cognitively healthy individuals and 98 individuals with AD to characterize changes in regional gray and white matter T1-weighted signal intensities in dementia and to evaluate how such measures related to classically described hippocampal and cortical atrophy. We found a reduction in gray matter to white matter tissue contrast throughout portions of medial and lateral temporal cortical regions as well as in anatomically associated regions including the posterior cingulate, precuneus, and medial frontal cortex. Decreases in tissue contrast were associated with hippocampal volume, however, the regional patterns of these associations differed for demented and nondemented individuals. In nondemented controls, lower hippocampal volume was associated with decreased gray/white matter tissue contrast globally across the cortical mantle. In contrast, in individuals with AD, selective associations were found between hippocampal volume and tissue contrast in temporal and limbic tissue. These results demonstrate that there are strong regional changes in neural tissue properties in AD which follow a spatial pattern including regions known to be affected from pathology studies. Such changes are associated with traditional imaging metrics of degeneration and may provide a unique biomarker of the tissue loss that occurs as a result of AD. |
| | |
Authors:
|
D H Salat; J J Chen; A J van der Kouwe; D N Greve; B Fischl; H D Rosas |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-18 |
Journal Detail:
|
Title: NeuroImage Volume: 54 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2010-12-21 Completed Date: 2011-03-31 Revised Date: 2012-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
|
Languages: eng Pagination: 1795-802 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Inc. |
Affiliation:
|
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129-2060, USA. salat@nmr.mgh.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Alzheimer Disease / cerebrospinal fluid, pathology*, psychology Entorhinal Cortex / pathology Female Hippocampus / pathology* Humans Image Processing, Computer-Assisted Limbic System / pathology* Magnetic Resonance Imaging Male Middle Aged Nerve Degeneration / pathology* Nerve Fibers, Myelinated / pathology Neuropsychological Tests Parahippocampal Gyrus / pathology Reproducibility of Results Temporal Lobe / pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
BIRN002//PHS HHS; K01 AG024898-01A1/AG/NIA NIH HHS; K01 AG024898-02/AG/NIA NIH HHS; K01 AG024898-03/AG/NIA NIH HHS; K01 AG024898-03S1/AG/NIA NIH HHS; K01 AG024898-04/AG/NIA NIH HHS; K01 AG024898-05/AG/NIA NIH HHS; K01AG024898/AG/NIA NIH HHS; P01 AG003991-16/AG/NIA NIH HHS; P01 AG03991/AG/NIA NIH HHS; P41 RR014075-117867/RR/NCRR NIH HHS; P41RR14075/RR/NCRR NIH HHS; P50 AG005681-18/AG/NIA NIH HHS; P50 AG05681/AG/NIA NIH HHS; P50 MH071616/MH/NIMH NIH HHS; R01 AG021910/AG/NIA NIH HHS; R01 EB006758-02/EB/NIBIB NIH HHS; R01 EB006758-04/EB/NIBIB NIH HHS; R01 MH056584-02/MH/NIMH NIH HHS; R01 MH56584/MH/NIMH NIH HHS; R01 NR010827-01A1/NR/NINR NIH HHS; R01 NR010827-02/NR/NINR NIH HHS; R01 NR010827-03/NR/NINR NIH HHS; R01 NR010827-04/NR/NINR NIH HHS; R01 NR010827-04S1/NR/NINR NIH HHS; R01 NR010827-05/NR/NINR NIH HHS; R01 NS052585-02/NS/NINDS NIH HHS; R01EB001550/EB/NIBIB NIH HHS; R01EB006758/EB/NIBIB NIH HHS; R01NR010827/NR/NINR NIH HHS; R01NS052585/NS/NINDS NIH HHS; U24 RR021382/RR/NCRR NIH HHS; U24 RR021382-01/RR/NCRR NIH HHS; U24RR021382/RR/NCRR NIH HHS; U54 EB005149-02/EB/NIBIB NIH HHS; U54 EB005149-050002/EB/NIBIB NIH HHS; U54EB005149/EB/NIBIB NIH HHS; //Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Unified segmentation based correction of R1 brain maps for RF transmit field inhomogeneities (UNICOR...
Next Document: Where sound position influences sound object representations: A 7-T fMRI study.