Document Detail

Hippocampal atrophy and neurocysticercosis calcifications.
MedLine Citation:
PMID:  15694560     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relationship between hippocampal atrophy (HA), neurocysticercosis calcifications (NC) and seizure semiology in patients with partial epilepsy.
METHODS: We identified two groups of patients: mesial temporal lobe epilepsy (MTLE) and extra-temporal epilepsy (ETE) patients. Each group was subdivided according to CT findings: normal, NC in the temporal regions, and NC in extra-temporal regions. MRI was obtained in a 2-T scanner and hippocampal volumetry was performed using 3-mm coronal T1-IR images. Hippocampal volumes below 2 standard deviations from the mean of the control group determined the presence of HA.
RESULTS: We studied 89 consecutive patients: 63 with MTLE and 26 with ETE. HA was found in 43/89 (49.5 %) patients, 42 of them with MTLE. There was no difference in frequency of HA in the comparison between patients with (25/50) and without NC (18/39) (chi(2), p=0.71). Furthermore, there was no relationship between localization of NC (temporal or extra-temporal) and seizure semiology (MTLE or ETE).
CONCLUSIONS: HA was more frequent and more severe in patients with MTLE, with no differences regarding the presence and localization of NC. These findings further support the concept that NC on CT not necessarily indicate the etiology of epilepsy and may represent only a co-existent pathology.
Cilene Nogueira da Gama; Eliane Kobayashi; Li M Li; Fernando Cendes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seizure     Volume:  14     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-06-14     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
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MeSH Terms
Brain Diseases / complications,  parasitology,  pathology
Calcinosis / pathology*
Epilepsy, Temporal Lobe / diagnosis,  etiology
Hippocampus / parasitology*,  pathology*,  radiography
Magnetic Resonance Imaging
Middle Aged
Neurocysticercosis / complications,  diagnosis,  parasitology*
Prospective Studies
Severity of Illness Index
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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