Document Detail

Hippocampal atrophy in temporal lobe epilepsy: the 'generator' and 'receiver'
MedLine Citation:
PMID:  21470191     Owner:  NLM     Status:  Publisher    
Bonilha L, Halford JJ, Morgan PS, Edwards JC. Hippocampal atrophy in temporal lobe epilepsy: the 'generator' and 'receiver'. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2011.01510.x. © 2011 John Wiley & Sons A/S. Objective -  Some patients with unilateral medial temporal lobe epilepsy (MTLE) display bilateral hippocampal atrophy on MRI, even though seizures originate in only one hippocampus. The correct identification of the epileptogenic hippocampus (the 'generator') vs the non-epileptogenic (the 'receiver') may lead to better surgical planning and results. Materials and Methods -  We studied 14 patients with MTLE (eight left and six right) who became seizure free after unilateral hippocampal resection, with hippocampal sclerosis confirmed by histology. Hippocampal tridimensional morphometry was performed comparing patients and healthy controls employing a voxel-wise Wilcoxon test. Results were corrected for multiple comparisons with the application of a False Discovery Rate (FDR)-corrected threshold for q < 0.05. Results -  Patients with MTLE showed atrophy involving the ipsilateral hippocampus and the contralateral hippocampus, more pronouncedly within the ipsilateral hippocampus in the anterior-inferior aspect of the hippocampal head (left MTLE, left hippocampus x = -28, y = -16, z = -24, Z = 3.6; right MTLE, right hippocampus x = 22, y = -11, z = -27, Z = 2.9). On the contralateral hippocampus, the atrophy was more noticeable in the posterior head and body areas. Conclusion -  The epileptogenic hippocampal atrophy has an anatomically distinct pattern compared with the contralateral hippocampus. This information may help guide the presurgical assessment of MTLE.
L Bonilha; J J Halford; P S Morgan; J C Edwards
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-6
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  -     ISSN:  1600-0404     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA Department of Radiology, Medical University of South Carolina, Charleston, SC, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Coping strategies as related to medical and demographic data in amyotrophic lateral sclerosis.
Next Document:  Dynamic cerebral autoregulation associates with infarct size and outcome after ischemic stroke.