| Hippocampal asymmetry and sudden unexpected death in infancy: a case report. | |
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MedLine Citation:
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PMID: 22864821 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The differential diagnosis of known entities associated with sudden unexpected death in infancy is ever expanding. Here we report the case of a 10-month-old infant boy whose clinical presentation mimicked that of the sudden infant death syndrome (SIDS). This presentation included the typical features of SIDS: sleep-related death; prone position upon discovery; and minor illness within 2 days of death. Nevertheless, neuropathologic examination revealed striking hippocampal asymmetry and microdysgenesis similar to that reported previously by us in toddlers with sleep-related sudden death. Hippocampal maldevelopment in the setting of sudden death in infants and toddlers is analogous to sudden unexpected death in epilepsy associated with temporal lobe pathology, and suggests a possible role for seizures in the terminal events leading to sudden death. This report serves to alert pediatric and forensic pathologists to hippocampal asymmetry and microdysgenesis in the differential diagnosis of sudden infant death mimicking SIDS. |
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Authors:
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Michael L Rodriguez; Kristin McMillan; Laura A Crandall; Megan E Minter; Marjorie R Grafe; Annapurna Poduri; Hannah C Kinney |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-4 |
Journal Detail:
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Title: Forensic science, medicine, and pathology Volume: - ISSN: 1556-2891 ISO Abbreviation: Forensic Sci Med Pathol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236111 Medline TA: Forensic Sci Med Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Forensic Medicine, Sydney Local Health District, Glebe, NSW, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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