Document Detail


Hippocampal asymmetry and sudden unexpected death in infancy: a case report.
MedLine Citation:
PMID:  22864821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The differential diagnosis of known entities associated with sudden unexpected death in infancy is ever expanding. Here we report the case of a 10-month-old infant boy whose clinical presentation mimicked that of the sudden infant death syndrome (SIDS). This presentation included the typical features of SIDS: sleep-related death; prone position upon discovery; and minor illness within 2 days of death. Nevertheless, neuropathologic examination revealed striking hippocampal asymmetry and microdysgenesis similar to that reported previously by us in toddlers with sleep-related sudden death. Hippocampal maldevelopment in the setting of sudden death in infants and toddlers is analogous to sudden unexpected death in epilepsy associated with temporal lobe pathology, and suggests a possible role for seizures in the terminal events leading to sudden death. This report serves to alert pediatric and forensic pathologists to hippocampal asymmetry and microdysgenesis in the differential diagnosis of sudden infant death mimicking SIDS.
Authors:
Michael L Rodriguez; Kristin McMillan; Laura A Crandall; Megan E Minter; Marjorie R Grafe; Annapurna Poduri; Hannah C Kinney
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-04
Journal Detail:
Title:  Forensic science, medicine, and pathology     Volume:  8     ISSN:  1556-2891     ISO Abbreviation:  Forensic Sci Med Pathol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-03-12     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101236111     Medline TA:  Forensic Sci Med Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology
Brain Edema / pathology
Forensic Pathology
Hippocampus / abnormalities*,  pathology*
Humans
Infant
Male
Organ Size
Sudden Infant Death / pathology*
Temporal Lobe / abnormalities*,  pathology*
Vertebral Artery / abnormalities,  pathology
Grant Support
ID/Acronym/Agency:
K23 NS069784/NS/NINDS NIH HHS; K23NS069784/NS/NINDS NIH HHS; R01 HD020991/HD/NICHD NIH HHS
Comments/Corrections

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