| Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI. | |
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MedLine Citation:
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PMID: 20938031 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: In Alzheimer disease (AD), mounting evidence points to a greater role for synaptic loss than neuronal loss. Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial loss of the CA1 pyramidal neurons themselves. In this cross-sectional study, we tested whether tissue loss in the CA1 apical neuropil layer can be observed in vivo in patients with mild AD. METHODS: We performed ultra-high-field 7-T MRI on subjects with mild AD (n = 14) and age-matched normal controls (n = 16). With a 2-dimensional T2*-weighted gradient-recalled echo sequence that was easily tolerated by subjects, we obtained cross-sectional slices of the hippocampus at an in-plane resolution of 195 μm. RESULTS: On images revealing the anatomic landmarks of hippocampal subfields and strata, we observed thinning of the CA1 apical neuropil in subjects with mild AD compared to controls. By contrast, the 2 groups exhibited no difference in the thickness of the CA1 cell body layer or of the entire CA1 subfield. Hippocampal volume, measured on a conventional T1-weighted sequence obtained at 3T, also did not differentiate these patients with mild AD from controls. CONCLUSIONS: CA1 apical neuropil atrophy is apparent in patients with mild AD. With its superior spatial resolution, 7-T MRI permits in vivo analysis of a very focal, early site of AD pathology. |
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Authors:
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G A Kerchner; C P Hess; K E Hammond-Rosenbluth; D Xu; G D Rabinovici; D A C Kelley; D B Vigneron; S J Nelson; B L Miller |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-10-29 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1381-7 Citation Subset: AIM; IM |
Affiliation:
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Stanford Center for Memory Disorders, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5235, USA. kerchner@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / complications, pathology* Atrophy / etiology, pathology CA1 Region, Hippocampal / pathology* Case-Control Studies Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods Male Mental Status Schedule Middle Aged Neuropil / pathology* Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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K23 AG031861-04/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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