Document Detail

Hippocampal atrophy relates to fluid intelligence decline in the elderly.
MedLine Citation:
PMID:  21092387     Owner:  NLM     Status:  MEDLINE    
Measures of brain and hippocampal volume in 40 healthy young (aged 18-30 years) and 36 healthy elderly (aged 60-83 years) subjects were compared with composite cognitive function scores in three conceptual domains: memory ability, processing speed, and general fluid intelligence. Through a series of general linear models testing the relationship between these brain measures and cognitive performance scores, a significant positive relationship between hippocampal volume and fluid intelligence ability was found in elderly subjects but not in young. No relationship between the other cognitive domains and brain or hippocampal volume was found. The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly.
Aaron Reuben; Adam M Brickman; Jordan Muraskin; Jason Steffener; Yaakov Stern
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-24
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  17     ISSN:  1469-7661     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-05     Completed Date:  2011-05-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-61     Citation Subset:  IM    
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MeSH Terms
Age Factors
Aged, 80 and over
Atrophy / pathology
Cognition Disorders / pathology*
Hippocampus / pathology*
Linear Models
Magnetic Resonance Imaging
Memory / physiology
Middle Aged
Neuropsychological Tests
Young Adult
Grant Support
K01 AG035061/AG/NIA NIH HHS; R01 AG026158/AG/NIA NIH HHS; R01 AG26158/AG/NIA NIH HHS

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