Document Detail

Hippocampal Agenesis in an Individual who Engaged in Violent Criminal Behaviors After Discontinuing Carbamazepine and Paroxetine Treatment.
MedLine Citation:
PMID:  22924995     Owner:  NLM     Status:  Publisher    
Antidepressant discontinuation syndrome (ADS) occurs after abrupt discontinuation of an antidepressant medication. A 23-year-old man with right hippocampal agenesis demonstrated sexual crime (hypersexuality) since the age of eight and had been successfully treated with carbamazepine since the age of 13. He had required increased doses of paroxetine and carbamazepine owing to the development of an unstable affect after quitting his job. He abruptly stopped taking his medication for 3 days and his criminal behaviors re-emerged. We examined changes in brain structure and activity before and after medication cessation, using MRI and functional MRI (fMRI). The image of a girl in a swimsuit increased activity in the thalamus only after medication discontinuation. The alteration in thalamic activity might induce hypersexuality. We conclude that a primary hypersexuality had been suppressed with carbamazepine and paroxetine treatment, and the discontinuation of the medication caused the hypersexuality.
Hiroaki Hanada; Jotaro Akiyoshi; Masayuki Kanehisa; Yoshinobu Ishitobi; Jusen Tsuru; Yoshihiro Tanaka; Tsuyoshi Shimomura; Yoshihisa Kawano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-24
Journal Detail:
Title:  Journal of forensic sciences     Volume:  -     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Academy of Forensic Sciences.
Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Oita, 879-5593, Japan.
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