Document Detail

Hippo-YAP and mTOR pathways collaborate to regulate organ size.
MedLine Citation:
PMID:  23196842     Owner:  NLM     Status:  In-Data-Review    
Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.
Alfred Csibi; John Blenis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1244-5     Citation Subset:  IM    
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115 Massachusetts. USA.
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