| Hippel-Lindau disease: MR imaging. | |
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MedLine Citation:
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PMID: 3336687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hippel-Lindau disease is an auto-somal-dominant disorder characterized by tumors arising from the central nervous system and abdominal viscera. Because of its progressive nature, frequent multisystem radiologic evaluation of affected persons and family members at risk is desirable for early detection and treatment. During a 2-year study, magnetic resonance (MR) imaging of the head, spine, and abdomen was used for screening and follow-up in 26 members of nine families with the disease. In addition to 13 previously diagnosed cases, five cases were newly diagnosed during the study. Lesions causing significant morbidity and mortality--such as cerebellar and spinal cord hemangioblastoma, renal cell carcinoma, and pheochromocytoma--were correctly depicted with MR imaging, sometimes before symptoms had developed and before the lesions could be seen with other imaging modalities. Central nervous system abnormalities were most clearly shown, but MR imaging also adequately demonstrated abdominal visceral abnormalities. It is therefore highly useful in the diagnosis and follow-up of Hippel-Lindau disease. |
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Authors:
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Y Sato; M Waziri; W Smith; E Frey; W T Yuh; J Hanson; E A Franken |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 166 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-01-28 Completed Date: 1988-01-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 241-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City 52242. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Gland Neoplasms / diagnosis Adult Angiomatosis / diagnosis* Brain Neoplasms / diagnosis Carcinoma, Renal Cell / diagnosis Female Hemangiosarcoma / diagnosis Humans Kidney Neoplasms / diagnosis Magnetic Resonance Imaging* Male Middle Aged Pheochromocytoma / diagnosis Spinal Cord Neoplasms / diagnosis von Hippel-Lindau Disease / diagnosis*, genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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