Document Detail

Hip implant evaluation in an arthritic animal model.
MedLine Citation:
PMID:  2383447     Owner:  NLM     Status:  MEDLINE    
Animal studies can provide important information in the evaluation of new techniques and prosthetic designs in orthopedics. As a prerequisite they must parallel as closely as possible the human conditions they are modeling. An arthritic sheep model simulating the human clinical situation has previously been designed and reported by Phillips and Gurr. The present study introduces for the first time an approach that evaluates a prosthetic joint in an arthritic animal hip. Hemiresurfacing following the Tharies technique was carried out unilaterally in 12 Suffolk sheep and followed up for 2 years. Femoral loosening occurred in three cases. Only one of the 12 cases showed postoperative avascularity of the femoral head. Radiologic follow-up and histologic examination showed features consistently and strikingly similar to those seen in human practice. The sheep hip with simulated arthritis provides a sensitive, clinically reproducible model for the future study of other arthroplasty types and problems.
T W Phillips; K R Gurr; D R Rao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of orthopaedic and trauma surgery     Volume:  109     ISSN:  0936-8051     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-17     Completed Date:  1990-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011043     Medline TA:  Arch Orthop Trauma Surg     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  194-6     Citation Subset:  IM    
Orthopedic Research Laboratory, St. Joseph's Health Center, London, Ontario, Canada.
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MeSH Terms
Arthritis / radiography,  surgery*
Bone Cements
Disease Models, Animal*
Evaluation Studies as Topic
Hip Joint / radiography
Hip Prosthesis*
Prostheses and Implants
Reg. No./Substance:
0/Bone Cements

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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