Document Detail


Hindquarters vasoconstriction through central GABA(B) receptors in conscious rats.
MedLine Citation:
PMID:  12861336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The exogenous application of GABA into the cisterna magna of the freely moving rat decreases hindquarters vascular tone as well as arterial pressure. GABA could influence GABA receptor subtypes A, B or C. However, the hindquarters vascular response to the stimulation of each receptor subtype has not yet been investigated. The present study therefore characterized the response to the GABA(B) receptor agonist baclofen injected into the cisterna magna of the conscious rat. Intracisternally injected baclofen induced long-lasting increases in hindquarters vascular resistance and arterial pressure in a dose-dependent manner. Both actions induced by baclofen were completely blocked by a prior intracisternal injection with the GABA(B) receptor antagonist CGP 35348 (p-[3-aminopropyl]-p-diethoxymethylphosphinic acid), and systemically by ganglionic blockade. These actions of baclofen were also abolished centrally by sodium pentobarbital anaesthesia. The results suggest that GABA(B) receptor stimulation via the cisterna magna induced hindquarters vasoconstriction, probably due to central disinhibition of sympathetic activity.
Authors:
Yumi Takemoto
Related Documents :
12815026 - Gaba transporter-1 (gat1)-deficient mice: differential tonic activation of gabaa versus...
15857696 - Imbalance between the expression of nk1 and gabab receptors in nociceptive spinal neuro...
12706246 - Gabab receptor subunits, r1 and r2, in brainstem catecholamine and serotonin neurons.
10587096 - Gaba(b) auto- versus hetero-receptor sensitivity: implications for novel pharmacotherapy.
16941076 - Lrrc4 controls in vitro invasion of glioblastoma cells through inhibiting rptp-zeta exp...
21794146 - Differential trafficking of ampa receptors following activation of nmda receptors and m...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  88     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2004-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Affiliation:
Neurophysiology, Hiroshima University Graduate School of Medical Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. yumitake@hiroshima-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Baclofen / pharmacology
Blood Pressure / drug effects,  physiology
Cisterna Magna
Consciousness
Dose-Response Relationship, Drug
GABA Antagonists / pharmacology
Hindlimb / blood supply*
Male
Organophosphorus Compounds / pharmacology
Rats
Rats, Wistar
Receptors, GABA-B / antagonists & inhibitors,  physiology*
Stimulation, Chemical
Sympathetic Nervous System / physiology
Vasoconstriction / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/GABA Antagonists; 0/Organophosphorus Compounds; 0/Receptors, GABA-B; 1134-47-0/Baclofen; 123690-79-9/CGP 35348

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of endothelin antagonists on the renal haemodynamic and tubular responses to ischaemia-reperf...
Next Document:  Effects of chronic systemic hypoxia on contraction evoked by noradrenaline in the rat iliac artery.