Document Detail

Hindquarters vasoconstriction through central GABA(B) receptors in conscious rats.
MedLine Citation:
PMID:  12861336     Owner:  NLM     Status:  MEDLINE    
The exogenous application of GABA into the cisterna magna of the freely moving rat decreases hindquarters vascular tone as well as arterial pressure. GABA could influence GABA receptor subtypes A, B or C. However, the hindquarters vascular response to the stimulation of each receptor subtype has not yet been investigated. The present study therefore characterized the response to the GABA(B) receptor agonist baclofen injected into the cisterna magna of the conscious rat. Intracisternally injected baclofen induced long-lasting increases in hindquarters vascular resistance and arterial pressure in a dose-dependent manner. Both actions induced by baclofen were completely blocked by a prior intracisternal injection with the GABA(B) receptor antagonist CGP 35348 (p-[3-aminopropyl]-p-diethoxymethylphosphinic acid), and systemically by ganglionic blockade. These actions of baclofen were also abolished centrally by sodium pentobarbital anaesthesia. The results suggest that GABA(B) receptor stimulation via the cisterna magna induced hindquarters vasoconstriction, probably due to central disinhibition of sympathetic activity.
Yumi Takemoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  88     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2004-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Neurophysiology, Hiroshima University Graduate School of Medical Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
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MeSH Terms
Baclofen / pharmacology
Blood Pressure / drug effects,  physiology
Cisterna Magna
Dose-Response Relationship, Drug
GABA Antagonists / pharmacology
Hindlimb / blood supply*
Organophosphorus Compounds / pharmacology
Rats, Wistar
Receptors, GABA-B / antagonists & inhibitors,  physiology*
Stimulation, Chemical
Sympathetic Nervous System / physiology
Vasoconstriction / drug effects,  physiology*
Reg. No./Substance:
0/GABA Antagonists; 0/Organophosphorus Compounds; 0/Receptors, GABA-B; 1134-47-0/Baclofen; 123690-79-9/CGP 35348

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