Document Detail


Hindering biofilm formation with zosteric acid.
MedLine Citation:
PMID:  20711895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antifoulant, zosteric acid, was synthesized using a non-patented process. Zosteric acid at 500 mg l(-1) caused a reduction of bacterial (Escherichia coli, Bacillus cereus) and fungal (Aspergillus niger, Penicillium citrinum) coverage by 90% and 57%, respectively. Calculated models allowed its antifouling activity to be predicted at different concentrations. Zosteric acid counteracted the effects of some colonization-promoting factors. Bacterial and fungal wettability was not affected, but the agent increased bacterial motility by 40%. A capillary accumulation test showed that zosteric acid did not act as a chemoeffector for E. coli, but stimulated a chemotactic response. Along with enhanced swimming migration of E. coli in the presence of zosteric acid, staining showed an increased production of flagella. Reverse transcriptase-PCR revealed an increased transcriptional level of the fliC gene and isolation and quantification of flagellar proteins demonstrated a higher flagellin amount. Biofilm experiments confirmed that zosteric acid caused a significant decrease in biomass (-92%) and thickness (-54%).
Authors:
Federica Villa; Domenico Albanese; Barbara Giussani; Philip S Stewart; Daniele Daffonchio; Francesca Cappitelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biofouling     Volume:  26     ISSN:  1029-2454     ISO Abbreviation:  Biofouling     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200331     Medline TA:  Biofouling     Country:  England    
Other Details:
Languages:  eng     Pagination:  739-52     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universita degli Studi di Milano, Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aspergillus niger / drug effects*,  physiology
Bacillus cereus / drug effects*,  physiology
Biofilms / drug effects*,  growth & development*
Biofouling / prevention & control
Biomass
Chemotaxis / drug effects
Cinnamates / chemical synthesis,  chemistry,  pharmacology*
Escherichia coli / drug effects*,  physiology
Flagella / metabolism
Flagellin / metabolism
Penicillium / classification,  drug effects*,  physiology
Sulfuric Acid Esters / chemical synthesis,  chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Cinnamates; 0/Sulfuric Acid Esters; 0/zosteric acid; 12777-81-0/Flagellin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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