| Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs. | |
| | |
MedLine Citation:
|
PMID: 11084552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model. |
| | |
Authors:
|
B W Paek; D L Farmer; C C Wilkinson; C T Albanese; W Peacock; M R Harrison; R W Jennings |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 183 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2000-12-04 Completed Date: 2000-12-14 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1119-23 Citation Subset: AIM; IM |
Affiliation:
|
Division of Pediatric Surgery, Department of Surgery, and The Fetal Treatment Center, University of California at San Francisco, 94143-0570, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Encephalocele / embryology*, etiology*, pathology, prevention & control Fetus / surgery* Meningomyelocele / complications*, embryology*, surgery Rhombencephalon* Sheep |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of urinary hyperglycosylated human chorionic gonadotropin concentration with the serum tr...
Next Document: The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma...