Document Detail


Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs.
MedLine Citation:
PMID:  11084552     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.
Authors:
B W Paek; D L Farmer; C C Wilkinson; C T Albanese; W Peacock; M R Harrison; R W Jennings
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  183     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1119-23     Citation Subset:  AIM; IM    
Affiliation:
Division of Pediatric Surgery, Department of Surgery, and The Fetal Treatment Center, University of California at San Francisco, 94143-0570, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Encephalocele / embryology*,  etiology*,  pathology,  prevention & control
Fetus / surgery*
Meningomyelocele / complications*,  embryology*,  surgery
Rhombencephalon*
Sheep

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