| Hind limb ischemia in rabbit model: T2-prepared versus time-of-flight MR angiography at 3 T. | |
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MedLine Citation:
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PMID: 17951349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively compare various parameters of vessels imaged at 3 T by using time-of-flight (TOF) and T2-prepared magnetic resonance (MR) angiography in a rabbit model of hind limb ischemia. MATERIALS AND METHODS: Experiments were approved by the institutional animal care and use committee. Endovascular occlusion of the left superficial femoral artery was induced in 14 New Zealand white rabbits. After 2 weeks, MR angiography and conventional (x-ray) angiography were performed. Vessel sharpness was evaluated visually in the ischemic and nonischemic limbs, and the presence of small collateral vessels was evaluated in the ischemic limbs. Vessel sharpness was also quantified by evaluating the magnitude of signal intensity change at the vessel borders. RESULTS: The sharpness of vessels in the nonischemic limbs was similar between the TOF and the T2-prepared images. In the ischemic limbs, however, T2-prepared imaging, as compared with TOF imaging, generated higher vessel sharpness in arteries with diminished blood flow (mean vessel sharpness: 44% vs 30% for popliteal arteries, 45% vs 28% for saphenous arteries; P < .001 for both comparisons) and enabled better detection of small collateral vessels (93% vs 36% of vessels, P < .001). CONCLUSION: T2-prepared imaging can facilitate high-spatial-resolution MR angiography of small vessels with low blood flow and thus has potential as a tool for noninvasive evaluation of arteriogenic therapies, without use of contrast material. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2452062067/DC1. |
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Authors:
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Grigorios Korosoglou; Wesley D Gilson; Michael Schär; Ali Ustun; Lawrence V Hofmann; Dara L Kraitchman; Matthias Stuber |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2007-10-19 |
Journal Detail:
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Title: Radiology Volume: 245 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-20 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 761-9 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2007. |
Affiliation:
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Russell H. Morgan Department of Radiology and Radiological Science, JHOC 4223, The Johns Hopkins University School of Medicine, 601 N Caroline St, Baltimore, MD, 21287, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hindlimb / blood supply* Ischemia / diagnosis* Magnetic Resonance Angiography / methods* Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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1 K08 EB004922-01/EB/NIBIB NIH HHS; R01-HL073223/HL/NHLBI NIH HHS; R01-HL084186/HL/NHLBI NIH HHS |
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