Document Detail

Highly specific and sensitive rise in Days 14-17 pro-alphaC inhibin with clinical pregnancy after frozen embryo transfer with ovulatory cycles.
MedLine Citation:
PMID:  17545687     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pro-alphaC inhibins are luteal derived analytes peaking in the maternal serum as early as Day 16 after conception. We set out to verify a previous post hoc analysis which suggested that pro-alphaC levels measured this early are extremely sensitive in predicting clinical pregnancy success after unstimulated IVF with ovulatory cycles. METHODS: Prospective observational study of 246 women undergoing frozen embryo transfer with ovulatory cycles. Serum pro-alphaC and beta-HCG levels at 14-17 days after conception were measured by enzyme-linked immunosorbent assay and grouped according to whether a clinical pregnancy occurred (demonstrable cardiac activity at > or =6 weeks' gestation). RESULTS: Of 34 (13.8%) women who achieved a clinical pregnancy, median (25th-75th centile) Days 14-17 pro-alphaC levels were 995 pg/ml (758-1463), 6- to 7-fold higher than levels observed in the remainder who did not fall pregnant (112.8 pg/ml (104-121); P < 0.0001). At a fixed 95% specificity, pro-alphaC was 100% sensitive in predicting clinical pregnancy. The best specificities achieved at 100% sensitivity were; 94.8% for pro-alphaC, 96.7% for beta-HCG and 98.1% when both analytes were combined. CONCLUSIONS: Clinical pregnancy is always associated with a release of luteal derived pro-alphaC 14-17 days after conception. Pro-alphaC may play a possible biological role and be a useful clinical biomarker of luteal health.
S Tong; L Rombauts; J Onwude; B Marjono; E M Wallace
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Publication Detail:
Type:  Journal Article     Date:  2007-06-02
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  22     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2249-53     Citation Subset:  IM    
Centre for Women's Health Research, Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton 3168, Victoria, Australia.
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MeSH Terms
Embryo Transfer*
Fertilization in Vitro*
Inhibins / blood*
Pregnancy Rate
Prospective Studies
Protein Precursors / blood*
Sensitivity and Specificity
Reg. No./Substance:
0/Protein Precursors; 0/inhibin-alpha subunit precursor; 57285-09-3/Inhibins

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