Document Detail

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases.
MedLine Citation:
PMID:  19919970     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. METHODS: Fifty consecutive SM patients with stable COPD and a mean age 46.3 +/- 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. RESULTS: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 +/- 0.76 L (58.98% +/- 17.51% predicted). The mean serum hs-CRP was 9.4 +/- 6.78 SD and 3.9 +/- 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). CONCLUSIONS: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.
Davood Attaran; Shahrzad M Lari; Mohammad Khajehdaluee; Hossein Ayatollahi; Mohammad Towhidi; Amir Asnaashari; Hassan Ghobadi Marallu; Maryam Mazloomi; Mahdi Balali Mood
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  28     ISSN:  1477-0903     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  739-45     Citation Subset:  IM    
Lung disease and tuberculosis research center, Mashhad University of Medical Sciences, Iran.
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MeSH Terms
C-Reactive Protein / metabolism*
Chemical Warfare Agents / poisoning*
Cross-Sectional Studies
Disease Progression
Lung Diseases / blood*,  chemically induced*,  pathology
Middle Aged
Mustard Gas / poisoning*
Nephelometry and Turbidimetry
Physical Examination
Pulmonary Disease, Chronic Obstructive / chemically induced,  pathology
Respiratory Function Tests
Respiratory Tract Diseases / blood*,  chemically induced*,  pathology
Reg. No./Substance:
0/Chemical Warfare Agents; 505-60-2/Mustard Gas; 9007-41-4/C-Reactive Protein

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