| Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases. | |
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MedLine Citation:
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PMID: 19919970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. METHODS: Fifty consecutive SM patients with stable COPD and a mean age 46.3 +/- 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. RESULTS: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 +/- 0.76 L (58.98% +/- 17.51% predicted). The mean serum hs-CRP was 9.4 +/- 6.78 SD and 3.9 +/- 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). CONCLUSIONS: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning. |
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Authors:
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Davood Attaran; Shahrzad M Lari; Mohammad Khajehdaluee; Hossein Ayatollahi; Mohammad Towhidi; Amir Asnaashari; Hassan Ghobadi Marallu; Maryam Mazloomi; Mahdi Balali Mood |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human & experimental toxicology Volume: 28 ISSN: 1477-0903 ISO Abbreviation: Hum Exp Toxicol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 739-45 Citation Subset: IM |
Affiliation:
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Lung disease and tuberculosis research center, Mashhad University of Medical Sciences, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged C-Reactive Protein / metabolism* Chemical Warfare Agents / poisoning* Cross-Sectional Studies Disease Progression Humans Iran Lung Diseases / blood*, chemically induced*, pathology Male Middle Aged Mustard Gas / poisoning* Nephelometry and Turbidimetry Physical Examination Pulmonary Disease, Chronic Obstructive / chemically induced, pathology Respiratory Function Tests Respiratory Tract Diseases / blood*, chemically induced*, pathology Veterans |
| Chemical | |
Reg. No./Substance:
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0/Chemical Warfare Agents; 505-60-2/Mustard Gas; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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