Document Detail

Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis.
MedLine Citation:
PMID:  20138834     Owner:  NLM     Status:  MEDLINE    
Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C12(EO)21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.
Tomomi Towata; Yuji Komizu; Shinya Suzu; Ryuichi Ueoka; Seiji Okada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-06
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  393     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
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MeSH Terms
Cell Line, Tumor
Cell Membrane / metabolism
Dimyristoylphosphatidylcholine / chemistry,  metabolism*
Liposomes / chemistry,  metabolism*
Lymphoma, Primary Effusion / metabolism*
Membrane Fluidity
Membrane Fusion
Polyethylene Glycols / chemistry,  metabolism*
Reg. No./Substance:
0/Liposomes; 0/Polyethylene Glycols; 13699-48-4/Dimyristoylphosphatidylcholine; 9002-92-0/polidocanol

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