Document Detail


Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives.
MedLine Citation:
PMID:  11574007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[reaction: see text] Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.
Authors:
L Anastasia; Negishi Ei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Organic letters     Volume:  3     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-27     Completed Date:  2001-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3111-3     Citation Subset:  IM    
Affiliation:
Herbert C. Brown Laboratories of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Alkynes / chemical synthesis*,  chemistry
Iodobenzenes / chemistry*
Organometallic Compounds / chemistry*
Palladium / chemistry
Zinc / chemistry*
Grant Support
ID/Acronym/Agency:
GM36792/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Alkynes; 0/Iodobenzenes; 0/Organometallic Compounds; 7440-05-3/Palladium; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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