Document Detail

Highly malignant submandibular extraskeletal osteosarcoma in a young patient.
MedLine Citation:
PMID:  18242029     Owner:  NLM     Status:  MEDLINE    
Osteosarcoma is the most common primary malignant neoplasm of the bone. Rarely, osteosarcomas occur at sites other than the bone, so-called extraskeletal osteosarcoma (ESOS). ESOS is a rare malignancy that accounts for approximately 1% of all tissue sarcomas and present most commonly as a large soft tissue mass in the extremities. The patient was an 18-year-old Japanese man who presented with a stony hard mass in the left submandibular region. Fine-needle aspiration biopsy could not be performed due to the firmness of the mass. The patient underwent left selective neck dissection after enlargement of the mass. Three months after operation, the patient developed massive local recurrence of the tumor. We removed the tumor, encased by the muscles. Postoperatively, the patient received a course of radiotherapy. However, 4 months after the second operation, the patient developed left facial nerve palsy and complained of sudden hearing loss on the left side. The patient developed metastases and died after acute intracranial hemorrhage. To the best of our knowledge, this is the first report of a submandibular ESOS in a young man without history of radiotherapy or trauma.
Yuki Saito; Chie Miyajima; Kazunari Nakao; Takahiro Asakage; Masashi Sugasawa
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-01-31
Journal Detail:
Title:  Auris, nasus, larynx     Volume:  35     ISSN:  1879-1476     ISO Abbreviation:  Auris Nasus Larynx     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708170     Medline TA:  Auris Nasus Larynx     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  576-8     Citation Subset:  IM    
Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Bunkyo-ku, Hongo, Tokyo 113-8665, Japan.
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MeSH Terms
Calcinosis / diagnosis,  pathology,  surgery
Connective Tissue / pathology
Diagnosis, Differential
Disease Progression
Neck Muscles / pathology
Neoplasm Invasiveness / pathology
Neoplasm Recurrence, Local / diagnosis,  pathology,  surgery
Osteosarcoma / diagnosis*,  pathology,  surgery
Skull Neoplasms / diagnosis,  pathology
Submandibular Gland Neoplasms / diagnosis*,  pathology,  surgery
Temporal Bone
Tomography, X-Ray Computed

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