Document Detail


Highly localized positive contrast of small paramagnetic objects using 3D center-out radial sampling with off-resonance reception.
MedLine Citation:
PMID:  20740656     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In this article, we present a 3D imaging technique, applying center-out RAdial Sampling with Off-Resonance reception, to accurately depict and localize small paramagnetic objects with high positive contrast while suppressing long T(2) (*) components. The center-out RAdial Sampling with Off-Resonance reception imaging technique is a fully frequency-encoded 3D ultrashort echo time acquisition method, which uses a large excitation bandwidth and off-resonance reception. By manually introducing an offset, Δf(0), to the central reception frequency (f(0)), the typical radial signal pileup observed in 3D center-out sampling caused by a dipolar magnetic field disturbance can be shifted toward the source of the field disturbance, resulting in a hyperintense signal at the magnetic center of the small paramagnetic object. This was demonstrated both theoretically and using 1D time domain simulations. Experimental verification was done in a gel phantom and in inhomogeneous porcine tissue containing various objects with very different geometry and susceptibility, namely, subvoxel stainless steel spheres, a puncture needle, and paramagnetic brachytherapy seeds. In all cases, center-out RAdial Sampling with Off-Resonance reception was shown to generate high positive contrast exactly at the location of the paramagnetic object, as was confirmed by X-ray computed tomography.
Authors:
Peter R Seevinck; Hendrik de Leeuw; Clemens Bos; Chris J G Bakker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  65     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-56     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Affiliation:
Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. p.seevinck@umcutrecht.nl
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