Document Detail

Highly heterogeneous fiber genes in the two closely related adenovirus genome types Ad35p and Ad34a.
MedLine Citation:
PMID:  7831826     Owner:  NLM     Status:  MEDLINE    
Two adenovirus isolates from urine, Ad35p (from a bone marrow recipient) and Ad34a (from a hemorrhagic cystitis patient), were compared regarding their fiber gene organization and hemagglutinating capacity. The fiber serves as the ligand between the virus capsid and the host cell receptor. The Ad35p fiber gene encoded a 323-amino-acid protein, and the Ad34a fiber gene a 325 amino acid protein. The two fibers manifested 62.4% overall amino acid sequence homology, the differences predominantly occurring within the knob region where sequence homology was only 49.5%. The knob region of Ad34a was virtually identical to that of Ad11p which also causes hemorrhagic cystitis. Unlike all other known subgenus B adenoviruses, in the Ad35p fiber an asparagine constituted the C-terminus. Although both Ad34a and Ad35p viruses can hemagglutinate monkey erythrocytes, the hemagglutination inhibition test showed them to differ from each other in the epitopes expressed on the fibers.
Y F Mei; G Wadell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virology     Volume:  206     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-17     Completed Date:  1995-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  686-9     Citation Subset:  IM    
Department of Virology, Umeå University, Sweden.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U10271;  U10272
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MeSH Terms
Adenoviruses, Human / genetics*
Amino Acid Sequence
Base Sequence
Capsid / genetics*
Capsid Proteins*
DNA, Viral
Genome, Viral*
Molecular Sequence Data
Sequence Homology, Amino Acid
Species Specificity
Reg. No./Substance:
0/Capsid Proteins; 0/DNA, Viral; 0/hexon capsid protein, Adenovirus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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