Document Detail


Highly glycosylated tumour antigens: interactions with the immune system.
MedLine Citation:
PMID:  21265810     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A common phenotypic change in cancer is a dramatic transformation of cellular glycosylation. Functional studies of particular tumour-associated oligosaccharides are difficult to interpret conclusively, but carbohydrate-binding proteins are likely to contribute to progression of the tumour. This review discusses the potential role of CLRs (C-type lectin receptors), expressed by antigen-presenting cells of the immune system, in tumour recognition and immune modulation. Studies in recent years have provided significant insight into the immunomodulatory function of CLR during infections, but their role in cancer remains elusive; some strongly bind tumour cells and antigens, indicating participation in malignancy. The potential to use recombinant CLR as diagnostic tools will also be discussed.
Authors:
Eirikur Saeland; Yvette van Kooyk
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  39     ISSN:  1470-8752     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-26     Completed Date:  2011-04-26     Revised Date:  2011-10-27    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  388-92     Citation Subset:  IM    
Affiliation:
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Post Box 7057, 1007 MB Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Neoplasm / chemistry,  immunology*
Dendritic Cells / immunology
Glycoproteins / chemistry,  immunology
Glycosylation
Humans
Immune System / immunology*
Neoplasms / immunology,  pathology
Oligosaccharides / chemistry,  immunology
Polysaccharides / chemistry,  immunology
Tumor Markers, Biological / chemistry,  immunology
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Glycoproteins; 0/Oligosaccharides; 0/Polysaccharides; 0/Tumor Markers, Biological

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