Document Detail

Highly enantioselective gamma-amination of alpha,beta-unsaturated acycl chlorides with azodicarboxylates. Efficient synthesis of chiral gamma-amino acid derivatives.
MedLine Citation:
PMID:  21902208     Owner:  NLM     Status:  Publisher    
The cinchona alkaloids-catalyzed γ-amination of α,β-unsaturated acyl chlorides with azodicarboxylates was developed to give the corresponding dihydropyridazinones in good yields with high enantioselectivities. Reductive ring-opening of the dihydropyridazinones afforded series of cyclic and acyclic γ-amino acid derivatives in good yields with high enantiopurity.
Li-Tao Shen; Li-Hui Sun; Song Ye
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-8
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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