Document Detail

Highly enantioselective addition of phenylethynylzinc to aldehydes catalyzed by chiral cyclopropane-based amino alcohols.
MedLine Citation:
PMID:  24335619     Owner:  NLM     Status:  In-Data-Review    
The enantioselective addition of phenylethynylzinc to aldehydes catalyzed by a series of cyclopropane-based amino alcohol ligands 7 was investigated. The reactions afforded chiral propargylic alcohols in high yields (up to 96%) and with excellent enantioselectivities (up to 98% ee) under mild conditions. Furthermore, studies on the structural relationship show that the matching of the chiral center configuration is crucial to obtain the high enantioselectivity.
Bing Zheng; Zhiyuan Li; Feipeng Liu; Yanhua Wu; Junjian Shen; Qinghua Bian; Shicong Hou; Ming Wang
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Publication Detail:
Type:  Journal Article     Date:  2013-12-11
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  18     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  15422-33     Citation Subset:  IM    
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