Document Detail

Highly efficient ionization of phosphopeptides at low pH by desorption electrospray ionization mass spectrometry.
MedLine Citation:
PMID:  23338759     Owner:  NLM     Status:  MEDLINE    
A fast and novel strategy for efficient ionization of phosphopeptides in mixtures is reported, in which the sample is acidified to low pH to suppress the deprotonation of phosphate groups and then followed by direct analysis using liquid sample desorption electrospray ionization mass spectrometry (DESI-MS).
Ning Pan; Pengyuan Liu; Weidong Cui; Bo Tang; Jingmin Shi; Hao Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Analyst     Volume:  138     ISSN:  1364-5528     ISO Abbreviation:  Analyst     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-11-26     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  1321-4     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Hydrogen-Ion Concentration
Molecular Sequence Data
Phosphopeptides / chemistry*
Spectrometry, Mass, Electrospray Ionization / economics,  methods*
Grant Support
5P41RR000954-35/RR/NCRR NIH HHS; P41 GM103422/GM/NIGMS NIH HHS; P41 RR000954/RR/NCRR NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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