| A Highly Soluble MMP-9 Inhibitor for Potential Treatment of Dry Eye Syndrome. | |
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MedLine Citation:
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PMID: 22520332 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dry eye syndrome (DES) or keratoconjunctivitis sicca is an eye disease caused by the chronic lack of lubrication and moisture of the eye. The pathogenesis of DES involves the over-expression and over-activity of corneal Matrix Metalloproteinase 9 (MMP-9). We propose herein a new, non-symptomatic, approach for the treatment of DES based on the inhibition of MMP-9 by a new highly soluble molecule, designed as PES_103 that has been shown to inhibit MMP-9 both in vitro and in vivo. The efficacy of PES_103 in vivo and the potential benefits of this treatment in restoring tear production were studied in this work by using an animal model of reduced lacrimation. PES_103 did not show any significant corneal toxicity. |
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Authors:
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Mattia Mori; Emanuele De Lorenzo; Eugenio Torre; Marco Fragai; Cristina Nativi; Claudio Luchinat; Annarosa Arcangeli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-23 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: - ISSN: 1742-7843 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society. |
Affiliation:
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ProtEra Srl, Scientific Campus of the University of Florence, Sesto Fiorentino (Florence), Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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