Document Detail


Highly pathogenic avian influenza virus among wild birds in Mongolia.
MedLine Citation:
PMID:  22984464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mongolia combines a near absence of domestic poultry, with an abundance of migratory waterbirds, to create an ideal location to study the epidemiology of highly pathogenic avian influenza virus (HPAIV) in a purely wild bird system. Here we present the findings of active and passive surveillance for HPAIV subtype H5N1 in Mongolia from 2005-2011, together with the results of five outbreak investigations. In total eight HPAIV outbreaks were confirmed in Mongolia during this period. Of these, one was detected during active surveillance employed by this project, three by active surveillance performed by Mongolian government agencies, and four through passive surveillance. A further three outbreaks were recorded in the neighbouring Tyva Republic of Russia on a lake that bisects the international border. No HPAIV was isolated (cultured) from 7,855 environmental fecal samples (primarily from ducks), or from 2,765 live, clinically healthy birds captured during active surveillance (primarily shelducks, geese and swans), while four HPAIVs were isolated from 141 clinically ill or dead birds located through active surveillance. Two low pathogenic avian influenza viruses (LPAIV) were cultured from ill or dead birds during active surveillance, while environmental feces and live healthy birds yielded 56 and 1 LPAIV respectively. All Mongolian outbreaks occurred in 2005 and 2006 (clade 2.2), or 2009 and 2010 (clade 2.3.2.1); all years in which spring HPAIV outbreaks were reported in Tibet and/or Qinghai provinces in China. The occurrence of outbreaks in areas deficient in domestic poultry is strong evidence that wild birds can carry HPAIV over at least moderate distances. However, failure to detect further outbreaks of clade 2.2 after June 2006, and clade 2.3.2.1 after June 2010 suggests that wild birds migrating to and from Mongolia may not be competent as indefinite reservoirs of HPAIV, or that HPAIV did not reach susceptible populations during our study.
Authors:
Martin Gilbert; Losolmaa Jambal; William B Karesh; Amanda Fine; Enkhtuvshin Shiilegdamba; Purevtseren Dulam; Ruuragchaa Sodnomdarjaa; Khuukhenbaatar Ganzorig; Damdinjav Batchuluun; Natsagdorj Tseveenmyadag; Purevsuren Bolortuya; Carol J Cardona; Connie Y H Leung; J S Malik Peiris; Erica Spackman; David E Swayne; Damien O Joly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2012-09-11
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-03-12     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44097     Citation Subset:  IM    
Affiliation:
Wildlife Conservation Society, Bronx, New York, United States of America. mgilbert@wcs.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Wild / virology*
Birds / virology*
Disease Outbreaks / statistics & numerical data,  veterinary
Epidemiological Monitoring
Geography
Influenza A Virus, H5N1 Subtype / physiology*
Influenza in Birds / epidemiology,  virology*
Mongolia / epidemiology
Grant Support
ID/Acronym/Agency:
HHSN266200700005C//PHS HHS; HHSN266200700007C//PHS HHS; HHSN266200700009C//PHS HHS
Comments/Corrections
Erratum In:
PLoS One. 2012;7(10). doi:10.1371/annotation/2ced0370-4f34-4380-9ca9-954ba328e160

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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