| Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries. | |
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MedLine Citation:
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PMID: 21744818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable. |
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Authors:
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Craig E Stivala; Armen Zakarian |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-07-15 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 133 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-03 Completed Date: 2011-11-28 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 11936-9 Citation Subset: IM |
Copyright Information:
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© 2011 American Chemical Society |
Affiliation:
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Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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chemical synthesis*,
chemistry* Alkylation Amides / chemistry* Lithium / chemistry* Molecular Structure Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM077379/GM/NIGMS NIH HHS; R01 GM077379/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Amides; 7439-93-2/Lithium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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