Document Detail

Highly crosslinked polyethylene reduces wear in total hip arthroplasty at 5 years.
MedLine Citation:
PMID:  20458640     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although hip arthroplasty reliably relieves pain and improves function, problems have arisen with wear and osteolysis. Highly crosslinked polyethylene has been developed to address this problem although at present there is limited clinical evidence it does so longer term.
QUESTIONS/PURPOSES: We compared the in vivo wear of standard versus highly crosslinked polyethylene (HXLP) in primary total hip arthroplasty at a minimum of 5-year followup.
METHODS: We enrolled 122 patients in a prospective, double-blinded, randomized trial and followed them annually to assess their progress. Annual radiographs were analyzed using previously validated edge detection software to assess for two-dimensional, three-dimensional, and volumetric wear. The mean follow up was 5.5 years (range, 4.1 to 7 years).
RESULTS: The two-dimensional wear measurements for HXLP showed lower wear compared to the conventional group (0.05 mm/year versus 0.26 mm/year, respectively). Three-dimensional and volumetric wear were similarly lower in the HXLP group.
CONCLUSIONS: Highly crosslinked polyethylene undergoes substantially less wear than conventional polyethylene at medium term. The effect of hip arthroplasty longevity will need to be assessed with longer-term studies, but this may lead to a decreased need for revision as a result of less wear and osteolysis.
Jonathan Mutimer; Peter A Devane; Kathryn Adams; J Geoffrey Horne
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  468     ISSN:  1528-1132     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3228-33     Citation Subset:  AIM; IM    
Wakefield Hospitals, Wellington, New Zealand.
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MeSH Terms
Arthroplasty, Replacement, Hip / adverse effects,  instrumentation*
Double-Blind Method
Hip Joint / radiography,  surgery*
Hip Prosthesis*
Imaging, Three-Dimensional
Linear Models
Middle Aged
New Zealand
Osteolysis / etiology,  prevention & control
Prospective Studies
Prosthesis Design
Prosthesis Failure
Radiographic Image Interpretation, Computer-Assisted
Stress, Mechanical
Time Factors
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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