Document Detail

Highlights in nonhymenoptera anaphylaxis.
MedLine Citation:
PMID:  18596593     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The purpose of this review is to summarize new interesting findings in both research and clinical practice of nonhymenoptera anaphylaxis with particular emphasis on food and drug allergy. RECENT FINDINGS: Recent findings include some aspects of crossreactivity among betalactams, nonsteroidal anti-inflammatory drugs with special attention to an immunogenic metabolite of diclofenac and the mode of diclofenac-induced basophil degranulation. Also, new insights into the sometimes atypical anaphylaxis-like reactions after administration of monoclonal antibodies and the immunologic response to these molecules will be discussed, as well as the role of low-dose pholcodine exposure on the development of sensitization to neuromuscular blocking agents. In food-related anaphylaxis, a significant increase of incidents has been observed over the last few years, especially among children of less than 5 years of age. Unfortunately, the severity of subsequent reactions cannot be predicted from the reaction history. Tree nuts and peanuts are the most important elicitors of fatal food-induced anaphylaxis. SUMMARY: In food-related anaphylaxis, prospectively evaluated marker allergens that are indicative of a potential anaphylactic reaction are still lacking. The drug groups covered in this review are of special interest either due to their prominent role as allergens or due to new findings.
Kathrin Scherer; Barbara K Ballmer-Weber; Andreas J Bircher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  8     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
Allergy Unit, Department of Dermatology, University Hospital Basel, Basel, Switzerland.
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MeSH Terms
Allergens / adverse effects,  immunology
Anaphylaxis / chemically induced*,  epidemiology,  immunology,  physiopathology
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Antibodies, Monoclonal / adverse effects
Basophils / immunology*,  metabolism
Cell Degranulation
Child, Preschool
Drug Hypersensitivity / epidemiology*,  immunology*,  physiopathology
Food Hypersensitivity / epidemiology*,  immunology*,  physiopathology
Neuromuscular Blocking Agents / adverse effects
Nuts / adverse effects
beta-Lactams / adverse effects
Reg. No./Substance:
0/Allergens; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Neuromuscular Blocking Agents; 0/beta-Lactams

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