Document Detail


Higher virological effectiveness of NNRTI-based antiretroviral regimens containing nevirapine or efavirenz compared to a triple NRTI regimen as initial therapy in HIV-1-infected adults.
MedLine Citation:
PMID:  16452065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare outcomes of nonnucleoside reverse transcriptase inhibitors (NNRTIs) nevirapine or efavirenz versus abacavir-based regimens with a backbone of zidovudine and lamivudine as initial therapy of treatment-naive adults with HIV-1 infection in routine clinical care.
METHOD: All patients starting their first antiretroviral therapy with any of the studied regimens from January 1999 to December 2002 were included in the analysis. Rates of viral suppression (HIV-RNA below 50 copies/mL) and discontinuation of any component of the regimen were compared at 48 weeks.
RESULTS: Fifty-one patients started with one of the two NNRTI-based regimens and 49 started with the triple nucleoside regimen (3-NRTI). After 48 weeks, more patients in the NNRTI regimens (76.5%) than in the 3-NRTI (51.1%) regimen achieved a HIV-1 RNA level below the limit of detection (<1.7 log10 copies/mL; p = .008). Time to change the antiretroviral regimen was shorter with 3-NRTI (median [range]: 234 [139-329] days) than with NNRTI (346 [0-756] days) (p = .0901). More withdrawals related to drug toxicity or intolerance occurred with the 3-NRTI-based regimen.
CONCLUSION: In a routine clinical care setting, initial antiretroviral treatment with an NNRTI (nevirapine or efavirenz) plus zidovudine and lamivudine was virologically superior and safer than a 3-NRTI therapy (abacavir with the same NRTI backbone).
Authors:
María Jesús Pérez-Elías; Ana Moreno; Santiago Moreno; Dolores López; Antonio Antela; José Luis Casado; Fernando Dronda; Carolina Gutiérrez; Carmen Quereda; Enrique Navas; Víctor Abraira; Miguel Angel Rodríguez
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  HIV clinical trials     Volume:  6     ISSN:  1528-4336     ISO Abbreviation:  HIV Clin Trials     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-05-18     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  100936377     Medline TA:  HIV Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiretroviral Therapy, Highly Active / methods*
Benzoxazines
CD4 Lymphocyte Count
Cohort Studies
Dideoxynucleosides / therapeutic use
Female
HIV Infections / blood,  drug therapy*,  virology
HIV-1 / genetics,  growth & development*
Humans
Lamivudine / therapeutic use
Male
Multivariate Analysis
Nevirapine / therapeutic use*
Oxazines / therapeutic use*
Patient Compliance
Prospective Studies
RNA, Viral / blood
Reverse Transcriptase Inhibitors / therapeutic use*
Zidovudine / therapeutic use
Chemical
Reg. No./Substance:
0/Benzoxazines; 0/Dideoxynucleosides; 0/Oxazines; 0/RNA, Viral; 0/Reverse Transcriptase Inhibitors; 2T8Q726O95/Lamivudine; 4B9XT59T7S/Zidovudine; 99DK7FVK1H/Nevirapine; JE6H2O27P8/efavirenz; WR2TIP26VS/abacavir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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