Document Detail


Higher self-reported physical activity is associated with lower systolic blood pressure: the Dietary Intervention Study in Childhood (DISC).
MedLine Citation:
PMID:  17142523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Children participating in a dietary clinical trial were studied to (1) assess physical activity patterns in boys and girls longitudinally from late childhood through puberty and (2) determine the association of level of physical activity on systolic blood pressure, low-density lipoprotein cholesterol, and BMI. PATIENTS AND METHODS: In the Dietary Intervention Study in Childhood, a randomized clinical trial of a reduced saturated fat and cholesterol diet in 8- to 10-year-olds with elevated low-density lipoprotein, a questionnaire that determined time spent in 5 intensity levels of physical activity was completed at baseline and at 1 and 3 years. An estimated-metabolic-equivalent score was calculated for weekly activity; hours per week were calculated for intense activities. We hypothesized that weekly self-reported physical activity would be associated with lower systolic blood pressure, low-density lipoprotein, and BMI over 3 years. Longitudinal data analyses were performed for each outcome (systolic blood pressure, low-density lipoprotein, and BMI) by using generalized estimating equations with estimated-metabolic-equivalent score per week as the independent variable adjusted for visit, gender, and Tanner stage (BMI was included in models for systolic blood pressure and low-density lipoprotein). RESULTS: The initial study cohort comprised 663 youths (362 boys [mean age: 9.7 years] and 301 girls [mean age: 9.0 years], of whom 623 (94%) completed the 3-year visit. For every 100 estimated-metabolic-equivalent hours of physical activity, there was a decrease of 1.15 mmHg of systolic blood pressure. There was a 1.28 mg/dL decline in low-density lipoprotein for a similar energy expenditure. For BMI, an analysis of intense physical activity showed that for every 10 hours of intense activity, there was a trend toward significance with a 0.2 kg/m2 decrease. CONCLUSIONS: Children with elevated cholesterol levels who lead a more physically active lifestyle have lower systolic blood pressure and a trend toward lower low-density lipoprotein over a 3-year interval. Long-term participation in intense physical activity may reduce BMI as well.
Authors:
Samuel S Gidding; Bruce A Barton; Joanne A Dorgan; Sue Y S Kimm; Peter O Kwiterovich; Normal L Lasser; Alan M Robson; Victor J Stevens; Linda Van Horn; Denise G Simons-Morton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatrics     Volume:  118     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2006-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2388-93     Citation Subset:  AIM; IM    
Affiliation:
Nemours Cardiac Center, A.I. duPont Children's Hospital and Thomas Jefferson University, Wilmington, Delaware 19899, USA. sgidding@nemours.org
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure*
Body Mass Index
Child
Diet
Exercise
Female
Humans
Lipoproteins / blood
Longitudinal Studies
Male
Motor Activity / physiology*
Grant Support
ID/Acronym/Agency:
1 P20 RR020-173-01/RR/NCRR NIH HHS; U01-HL37947/HL/NHLBI NIH HHS; U01-HL37948/HL/NHLBI NIH HHS; U01-HL37954/HL/NHLBI NIH HHS; U01-HL37962/HL/NHLBI NIH HHS; U01-HL37966/HL/NHLBI NIH HHS; U01-HL37975/HL/NHLBI NIH HHS; U01-HL38110/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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