Document Detail


Higher relative risk of spondyloarthropathies among B27 positive Indonesian Chinese than native Indonesians.
MedLine Citation:
PMID:  8350336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the prevalence of HLA-B27 among ethnic Indonesian and Indonesian Chinese patients with ankylosing spondylitis (AS) or related spondyloarthropathies, and also among healthy controls. HLA-B27 was found in 23 (62.2%) of 37 Chinese patients and 4% of 176 Chinese healthy controls (p < 0.001). In contrasts only 2 (8.3%) of 24 native Indonesian patients and 13 (9%) of 145 healthy controls were HLA-B27+, indicating the lack of association of HLA-B27 with spondyloarthropathies in native Indonesians. These findings also suggest that HLA-B27 Chinese Indonesians carry a greater relative risk of developing AS and related spondyloarthropathies than native Indonesians, although the prevalence of HLA-B27 in the general population is more than 2 times higher in native Indonesians.
Authors:
A R Nasution; A Mardjuadi; N G Suryadhana; R Daud; S Muslichan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  20     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-14     Completed Date:  1993-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  988-90     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Indonesia, Jakarta.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
China / ethnology
Cross-Sectional Studies
Ethnic Groups / genetics
Female
Gene Frequency
HLA-B27 Antigen* / genetics
Humans
Indonesia / epidemiology
Male
Middle Aged
Rheumatic Diseases / epidemiology,  immunology
Risk Factors
Spinal Diseases / epidemiology,  immunology
Spondylitis, Ankylosing / epidemiology*,  genetics,  immunology*
Chemical
Reg. No./Substance:
0/HLA-B27 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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