| Higher relative risk of spondyloarthropathies among B27 positive Indonesian Chinese than native Indonesians. | |
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MedLine Citation:
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PMID: 8350336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the prevalence of HLA-B27 among ethnic Indonesian and Indonesian Chinese patients with ankylosing spondylitis (AS) or related spondyloarthropathies, and also among healthy controls. HLA-B27 was found in 23 (62.2%) of 37 Chinese patients and 4% of 176 Chinese healthy controls (p < 0.001). In contrasts only 2 (8.3%) of 24 native Indonesian patients and 13 (9%) of 145 healthy controls were HLA-B27+, indicating the lack of association of HLA-B27 with spondyloarthropathies in native Indonesians. These findings also suggest that HLA-B27 Chinese Indonesians carry a greater relative risk of developing AS and related spondyloarthropathies than native Indonesians, although the prevalence of HLA-B27 in the general population is more than 2 times higher in native Indonesians. |
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Authors:
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A R Nasution; A Mardjuadi; N G Suryadhana; R Daud; S Muslichan |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 20 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-09-14 Completed Date: 1993-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 988-90 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Indonesia, Jakarta. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child China / ethnology Cross-Sectional Studies Ethnic Groups / genetics Female Gene Frequency HLA-B27 Antigen* / genetics Humans Indonesia / epidemiology Male Middle Aged Rheumatic Diseases / epidemiology, immunology Risk Factors Spinal Diseases / epidemiology, immunology Spondylitis, Ankylosing / epidemiology*, genetics, immunology* |
| Chemical | |
Reg. No./Substance:
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0/HLA-B27 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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