Document Detail

Higher red cell distribution width values are associated with impaired exercise capacity during exercise treadmill testing in patients without obstructive coronary disease: a preliminary study.
MedLine Citation:
PMID:  24563439     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Red cell distribution width (RDW) is associated with poor cardiovascular outcomes. We aimed to find out if this association could be explained by impaired exercise capacity in patients without obstructive coronary artery disease (CAD).
PATIENTS AND METHODS: The patients who underwent exercise treadmill test (ETT) who have non-obstructive CAD and were free of heart failure symptoms were evaluated. Total of 132 patients were enrolled, and patients were divided into three groups according to their Metabolic Equivalent Task (MET) level measured by exercise treadmill test (ETT): Less than 7 METs (group 1), 7-10 METs (group 2) and greater than 10 METs (group 3).
RESULTS: The patients in Group 1 had significantly higher RDW levels (16.46 ± 2.79) compared to Group 2 (15.05 ± 2.03) and Group 3 (14.52 ± 1.37), independent of hemoglobin and hematocrit values. Significant differences for age, gender, duration of ETT and Duke Treadmill Score were also found in proportion to the reduced exercise capacity. In multivariate analysis, only duration of ETT (β = 1.017, p = < 0.001) and RDW (β = 0.040, p = 0.026) were found as independent variables, which had statistically significant effects on METs.
CONCLUSIONS: We found an independent association between RDW and exercise capacity in patients free of obstructive coronary disease suggesting that patients with elevated RDW values are expected to have impaired exercise capacity.
C Barcin; M Celik; U C Yuksel; H K Kabul; Y Gokoglan; E Yalcinkaya; S Yasar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  18     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-02-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
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