| Higher post-absorptive skeletal muscle LPL activity in African American vs. non-Hispanic White pre-menopausal women. | |
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MedLine Citation:
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PMID: 18223635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Higher post-absorptive post-heparin plasma lipoprotein lipase (LPL) activity has been reported in African Americans as compared to non-Hispanic whites but differences in tissue-specific LPL activity are unclear. METHODS AND PROCEDURES: Post-absorptive skeletal muscle (SM)-LPL (vastus lateralis ) and subcutaneous abdominal adipose tissue (AT)-LPL activity was measured in overweight, sedentary African American females (n = 11) as well as in their non-Hispanic white counterparts (n = 6) during a period of controlled low fat (30%) diet (for 10 days) combined with physical activity (for days 8-10). Post-absorptive substrate utilization was measured on day 10; fasting blood levels and SM and AT biopsies were obtained on day 11. RESULTS: African Americans had significantly greater post-absorptive SM-LPL activity (P = 0.04) when compared to non-Hispanic whites. There were no significant differences in post-absorptive AT-LPL activity, free fatty acids, and systemic fat oxidation or respiratory quotient between African American and white non-Hispanic women in this study (P > 0.2 for all). DISCUSSION: During a controlled low fat (30%) diet post-absorptive vastus lateralis SM-LPL activity is higher in sedentary pre-menopausal African American as compared to non-Hispanic white women. |
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Authors:
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Evan S Berk; Julia A Johnson; Mijeong Lee; Kuan Zhang; Carol N Boozer; F Xavier Pi-Sunyer; Susan K Fried; Jeanine B Albu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 16 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-04-08 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 199-201 Citation Subset: IM |
Affiliation:
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New York Obesity Research Center, St. Luke's Hospital, Columbia University, New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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enzymology,
pathology Adult African Americans / ethnology* Biopsy Diet, Fat-Restricted European Continental Ancestry Group / ethnology* Female Humans Lipoprotein Lipase / metabolism* Middle Aged Motor Activity Muscle, Skeletal / enzymology*, pathology Overweight / enzymology*, ethnology Postprandial Period Premenopause / ethnology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK52398/DK/NIDDK NIH HHS; M01 RR000645-330951/RR/NCRR NIH HHS; M0RR000645/RR/NCRR NIH HHS; P30K26687//PHS HHS; R01 DK040414-12/DK/NIDDK NIH HHS; R01 DK40414/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.34/Lipoprotein Lipase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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