| Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care. | |
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MedLine Citation:
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PMID: 20490889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate whether non-opioid antipyretic analgesics are associated with lower pain scores, opioid doses and side effects in pain patients in tertiary care. METHODS: In a cross-sectional observational study, data from 519 Caucasians (197 men, 322 women; mean age 55.6 ± 15 years) who had undertaken pain therapy for various causes for 77.5 ± 90.8 months, obtained in three separate study centres, was analysed for actual 24-h pain scores, daily opioid doses and the occurrence of side effects. RESULTS: Of the 519 patients, 352 received opioids and 260 antipyretic analgesics, from whom 154 received both classes and 304 only either class. The administration of non-opioid antipyretic analgesics was associated with higher average pain scores (4.6 ± 2.5 vs 3.9 ± 2.6; P = 0.01), tendentially higher average oral morphine equivalent doses (121.8 ± 162.2 vs 146.7 ± 242.4 mg/d; P = 0.25) and a similar incidence of side effects (P = 0.21). These results were correspondingly seen when analysing the three study centres separately as independent cohorts. CONCLUSIONS: With the caution advised for cross-sectional data, the results dispute a clinical benefit of non-opioid antipyretic analgesics for most chronic pain patients in tertiary care and draw attention towards prospectively re-evaluating the utility of non-opioid antipyretic analgesics in tertiary pain care in a randomised placebo controlled trial. |
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Authors:
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Jörn Lötsch; Rainer Freynhagen; Nils von Hentig; Norbert Griessinger; Michael Zimmermann; Reinhard Sittl; Gerd Geisslinger |
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Publication Detail:
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Type: Journal Article Date: 2010-05-20 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 59 ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 989-95 Citation Subset: IM |
Affiliation:
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Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University, Frankfurt am Main, Germany. j.loetsch@em.uni-frankfurt.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analgesics / therapeutic use* Analgesics, Opioid / therapeutic use* Antipyretics / therapeutic use* Cross-Sectional Studies Female Humans Male Middle Aged Pain / drug therapy* Pain Measurement* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Analgesics, Opioid; 0/Antipyretics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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