Document Detail


Higher natural killer cell activity in schizophrenic patients: the impact of serum factors, medication, and smoking.
MedLine Citation:
PMID:  10970677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schizophrenia has been associated with altered immunity and reduced occurrence of autoimmune diseases and malignancies. A few studies in schizophrenic patients have assessed natural killer cell activity (NKA), but no consistent findings have emerged. However, NKA was assessed using standard procedures and in the absence of autologous serum and the various cytokines that modulate NKA and appear to be abnormal in schizophrenic patients. In the current study, therefore, the number of NK cells and the activity of the individual NK cell were assessed in whole blood shortly after blood withdrawal, in both the presence and the absence of autologous serum. Twenty-nine schizophrenic patients (11 nonmedicated), 8 nonschizophrenic control patients (bipolar and personality disorders), and 31 age-matched healthy controls were studied. Schizophrenic patients showed higher NKA per NK cell than controls and nonschizophrenic patients. This difference remained significant even when the nonmedicated schizophrenics, who showed the highest levels of NKA, were excluded. However, the increase in NKA was more pronounced in the presence of serum and was reduced to an insignificant level when serum was removed from the same samples. In both schizophrenic patients and controls, smokers and women showed lower NKA. Numbers of NK cells did not differ among groups, although medication affected blood concentration of other leukocytes. These findings indicate that the effects of serum factors, psychiatric medication, gender, and smoking should be considered when assessing NKA in schizophrenic patients. The observed higher NKA may help explain the surprising reports of low incidence of lung cancer and other malignancies in schizophrenic patients, despite their higher rate of smoking.
Authors:
G Yovel; P Sirota; D Mazeh; G Shakhar; E Rosenne; S Ben-Eliyahu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  14     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-13     Completed Date:  2000-10-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-69     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Department of Psychology, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / therapeutic use*
Bipolar Disorder / blood,  drug therapy,  physiopathology
Cell Count / drug effects
Female
Humans
Killer Cells, Natural / pathology,  physiology*
Leukocytes / pathology
Male
Middle Aged
Personality Disorders / blood,  drug therapy,  physiopathology
Schizophrenia / blood*,  drug therapy,  physiopathology*
Sex Characteristics
Smoking / adverse effects*
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
CA73056/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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