| Higher n-3 fatty acids are associated with more intense fenfluramine induced ACTH and cortisol responses among cocaine abusing men. | |
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MedLine Citation:
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PMID: 21658782 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preclinical studies have shown that diets supplemented with or deficient in n-3 polyunsaturated fatty acids (PUFAs) could influence serotonergic neurotransmission but information about their effects on the serotonergic function of humans is scant. Therefore simultaneous assessments of n-3 PUFAs and of the ACTH and cortisol responses to challenges with the serotonin (5-HT) probe, d,l-fenfluramine (FEN) were performed in 25 cocaine abusing men and 12 control subjects. Cocaine abusers were tested 18days after their admission to a closed ward. ACTH and cortisol were measured in plasma samples collected on two testing days separated by 48h following the random administration of 60mg of FEN or placebo. Fatty acids were measured in the first test day samples. Patients' FEN-induced ACTH rises were significantly and positively correlated with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Patients' cortisol rises were positively and significantly correlated with EPA but not with DHA. There were no significant correlations between hormonal responses and pre-hospitalization cocaine use parameters. Control subjects' responses to FEN were not correlated with any PUFA. In conclusion, higher EPA and DHA levels were associated with a more intense FEN-induced ACTH response and higher EPA levels with a more intense cortisol response in cocaine abusing men withdrawn from cocaine but not in control subjects. These findings support and expand existing evidence that EPA and DHA could influence 5-HT function in some human subgroups. |
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Authors:
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Laure Buydens-Branchey; Marc Branchey; Joseph R Hibbeln |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-7 |
Journal Detail:
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Title: Psychiatry research Volume: - ISSN: 0165-1781 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Narrows Institute for Biomedical Research, Brooklyn, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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