Document Detail

Higher n-3 fatty acids are associated with more intense fenfluramine-induced ACTH and cortisol responses among cocaine-abusing men.
MedLine Citation:
PMID:  21658782     Owner:  NLM     Status:  MEDLINE    
Preclinical studies have shown that diets supplemented with or deficient in n-3 polyunsaturated fatty acids (PUFAs) could influence serotonergic neurotransmission, but information about their effects on the serotonergic function of humans is scant. Therefore, simultaneous assessments of n-3 PUFAs and of the adrenocorticotropic hormone (ACTH) and cortisol responses to challenges with the serotonin (5-HT) probe d,l-fenfluramine (FEN) were performed in 25 cocaine-abusing men and 12 control subjects. Cocaine abusers were tested 18 days after their admission to a closed ward. ACTH and cortisol were measured in plasma samples collected on two testing days separated by 48 h following the random administration of 60 mg of FEN or placebo. Fatty acids were measured in the first test day samples. Patients' FEN-induced ACTH rises were significantly and positively correlated with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Patients' cortisol rises were positively and significantly correlated with EPA but not with DHA. There were no significant correlations between hormonal responses and pre-hospitalization cocaine use parameters. Control subjects' responses to FEN were not correlated with any PUFA. In conclusion, higher EPA and DHA levels were associated with a more intense FEN-induced ACTH response and higher EPA levels with a more intense cortisol response in cocaine-abusing men withdrawn from cocaine but not in control subjects. These findings support and expand existing evidence that EPA and DHA could influence 5-HT function in some human subgroups.
Laure Buydens-Branchey; Marc Branchey; Joseph R Hibbeln
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-06-11
Journal Detail:
Title:  Psychiatry research     Volume:  188     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-29     Completed Date:  2011-09-27     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Copyright Information:
2011 Elsevier Ltd. All rights reserved.
Narrows Institute for Biomedical Research, Brooklyn, NY 11209, USA.
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MeSH Terms
Adrenocorticotropic Hormone / blood*
Chromatography, Gas
Cocaine-Related Disorders / blood*,  psychology
Criminals / psychology
Double-Blind Method
Fatty Acids, Omega-3 / blood*
Fenfluramine / diagnostic use*
Follow-Up Studies
Hydrocortisone / blood*
Middle Aged
Psychological Tests
Regression Analysis
Serotonin Uptake Inhibitors / diagnostic use*
Time Factors
Grant Support
R01 DA015360-03/DA/NIDA NIH HHS; R01-DA15360/DA/NIDA NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Serotonin Uptake Inhibitors; 458-24-2/Fenfluramine; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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