| Higher levels of organization in the interphase nucleus of cycling and differentiated cells. | |
| | |
MedLine Citation:
|
PMID: 10704477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The review examines the structured organization of interphase nuclei using a range of examples from the plants, animals, and fungi. Nuclear organization is shown to be an important phenomenon in cell differentiation and development. The review commences by examining nuclei in dividing cells and shows that the organization patterns can be dynamic within the time frame of the cell cycle. When cells stop dividing, derived differentiated cells often show quite different nuclear organizations. The developmental fate of nuclei is divided into three categories. (i) The first includes nuclei that undergo one of several forms of polyploidy and can themselves change in structure during the course of development. Possible function roles of polyploidy is given. (ii) The second is nuclear reorganization without polyploidy, where nuclei reorganize their structure to form novel arrangements of proteins and chromosomes. (iii) The third is nuclear disintegration linked to programmed cell death. The role of the nucleus in this process is described. The review demonstrates that recent methods to probe nuclei for nucleic acids and proteins, as well as to examine their intranuclear distribution in vivo, has revealed much about nuclear structure. It is clear that nuclear organization can influence or be influenced by cell activity and development. However, the full functional role of many of the observed phenomena has still to be fully realized. |
| | |
Authors:
|
A R Leitch |
Related Documents
:
|
17520687 - Cell cycle dependent phosphorylation and subnuclear organization of the histone gene re... 6738537 - Phosphorylation of histones in cells treated with hypertonic and acidic media. 11007437 - Nuclear dna content and chromatin pattern of rat rhabdomyosarcoma cell sublines with di... 11742087 - Histone deacetylase inhibitors reduce polyglutamine toxicity. 11182257 - Reactive oxygen species uncouple external horizontal cells in the carp retina and gluta... 14511467 - Tissue regeneration based on growth factor release. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Microbiology and molecular biology reviews : MMBR Volume: 64 ISSN: 1092-2172 ISO Abbreviation: Microbiol. Mol. Biol. Rev. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-04-25 Completed Date: 2000-04-25 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9706653 Medline TA: Microbiol Mol Biol Rev Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 138-52 Citation Subset: IM |
Affiliation:
|
Queen Mary and Westfield College, University of London, London, United Kingdom. A.R.Leitch@qmw.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation / genetics* Cell Nucleus / genetics*, ultrastructure* Chromatin / genetics, metabolism, ultrastructure Chromosomes / chemistry, physiology, ultrastructure Humans Interphase / genetics* Nuclear Proteins / genetics, metabolism Polyploidy |
| Chemical | |
Reg. No./Substance:
|
0/Chromatin; 0/Nuclear Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetics of mosquito vector competence.
Next Document: Microbial relatives of the seed storage proteins of higher plants: conservation of structure and div...