Document Detail

Higher levels of HIV DNA in memory and naive CD4(+) T cell subsets of viremic compared to non-viremic patients after 18 and 24 months of HAART.
MedLine Citation:
PMID:  11397507     Owner:  NLM     Status:  MEDLINE    
The degree of infection of memory and naive CD4(+) T cells in patients treated with HAART and with durable undetectable or detectable viral load in plasma was evaluated. The following two groups of patients were analyzed cross-sectionally: (i) patients with undetectable HIV RNA plasma levels during follow-up (responders); (ii) patients with no reduction or with rebound in HIV RNA levels during treatment (non-responders). Patients were examined following 6, 12, 18 and 24 months of HAART, respectively, by quantifying: (i) plasma HIV RNA load; (ii) CD4(+) T cells; (iii) memory and naive CD4(+) T cells; (iv) HIV DNA levels in memory and naive CD4(+) T cells. HIV RNA plasma levels were significantly higher in non-responders vs responders at each time point (P<0.02), while CD4(+) T cell counts as well as memory and naive CD4(+) T cell levels were comparable in both viremic and non-viremic patients. However, higher HIV DNA values were observed in both memory and naive CD4(+) T cells of non-responders vs responders after 18 and 24 months of HAART (P<0.02), suggesting an increased amount of HIV-infected naive CD4(+) T cells and a sustained high degree of infection of memory CD4(+) T cells. Immunological reconstitution following HAART might potentially be hampered in viremic patients despite the absolute increase in CD4(+) T cell counts.
F Baldanti; S Paolucci; R Gulminetti; R Maserati; G Migliorino; A Pan; F Maggiolo; G Comolli; A Chiesa; G Gerna
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antiviral research     Volume:  50     ISSN:  0166-3542     ISO Abbreviation:  Antiviral Res.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-08     Completed Date:  2001-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  197-206     Citation Subset:  IM    
Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Via Taramelli 5, 27100 Pavia, Italy.
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MeSH Terms
Anti-HIV Agents / therapeutic use*
Antigens, CD45 / immunology*
Antiretroviral Therapy, Highly Active*
CD4-Positive T-Lymphocytes / virology*
Cross-Sectional Studies
DNA, Viral / blood*
Flow Cytometry
Follow-Up Studies
HIV Infections / drug therapy*,  immunology,  virology*
HIV-1 / drug effects,  genetics*
Immunologic Memory*
L-Selectin / immunology*
Polymerase Chain Reaction
RNA, Viral / blood
T-Lymphocyte Subsets / virology*
Viral Load
Viremia / blood,  drug therapy,  immunology*
Reg. No./Substance:
0/Anti-HIV Agents; 0/DNA, Viral; 0/RNA, Viral; 126880-86-2/L-Selectin; EC, CD45

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