Document Detail


Higher leukocyte count is associated with higher risk of 3-year mortality in non-diabetic patients with first-ever ischemic stroke.
MedLine Citation:
PMID:  22336697     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Leukocyte count predicted the risk of first-time myocardial infarction and ischemic stroke. The aim of this study was to determine the role of elevated leukocyte count in non-diabetic patients admitted for acute first-ever ischemic stroke on clinical presentation and 3-year mortality. We studied 462 patients with acute first-ever ischemic stroke without diabetes mellitus or active infection at admission. Patients were classified into 2 groups according to their leukocyte count. A white blood cell (WBC) count ≥10,000/μL was defined as an elevated leukocyte count, otherwise as normal. Clinical presentation, risk factors for stroke, laboratory data, co-morbidities, and outcomes were recorded. 64 patients (13.9%) had elevated leukocytes. Multivariate logistic regression showed that an elevated platelet count was positively associated with the elevated leukocyte count, while a low serum sodium level was negatively associated with an elevated leukocyte count (P=0.008, P=0.003, respectively). An elevated leukocyte count was associated with a higher risk of a stroke in evolution (P=0.021). Multivariate Cox regression analysis revealed that an elevated leukocyte count is a significant predictor of 3-year mortality [P=0.010, HR=3.26 (1.33-7.98)]. In conclusion, higher leukocyte counts during the acute stroke stage are associated with increased risk of 3-year mortality in patients with acute, first-ever ischemic stroke.
Authors:
Wen-Yi Huang; Tsung-I Peng; Wei-Chieh Weng; Yu-Yi Chien; Chia-Lun Wu; Meng Lee; Kuan-Hsing Chen
Related Documents :
22131737 - Clinical effect of matra basti and vatari guggulu in the management of amavata (rheumat...
22549687 - Temporomandibular disorders. a case-control study.
22553947 - The risk of osteopenia in premenopausal women with various sellar tumors.
22024997 - Differences in brain natriuretic peptide value between transient ischemic attack and st...
19924537 - Endoscopic appearance of the minor papilla predicts findings at pancreatography.
21067327 - Characteristics and consequences of airway colonization by filamentous fungi in 201 adu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-13
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurology, Chang-Gung Memorial Hospital, Keelung branch, Taiwan, School of Medicine, Chang-Gung University, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Uses of the postural stability test for differential diagnosis of hereditary ataxias.
Next Document:  Detecting cognitive fatigue in multiple sclerosis: Method matters.